Indian Journal of Nuclear Medicine
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Year : 2006  |  Volume : 21  |  Issue : 2  |  Page : 32-35

Comparison of Gallium-67 and Tc-99m Tetrofosmin Uptake in Lymphoma

Dept. of Nuclear Medicine, Cancer Institute (WIA), Chennai - 600020, India

Correspondence Address:
R Krishnakumar
Department of Nuclear Medicine Cancer Institute (WIA), Adyar, Chennai 600 020
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Source of Support: None, Conflict of Interest: None

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Scintigraphic evaluation of lymphomas with Gallium67 (Ga-67) pre & post-therapy is well-established procedure. Other agents employed include 18 Fluoro Deoxy Glucose (FDG) and Thallium chloride (Tl- 201). However Ga-67, 18FDG and Tl-201 are all cyclotron produced and are not readily available in developing countries like India. In this context assuming similarity of behavior with the myocardial perfusion scanning agent Tl- 201, the newer Technetium-99m (Tc-99m) labeled myocardial perfusion scanning agents have been studied in imaging of various tumors. Methods: 13 patients of lymphoma -Hodgkin's disease (HD) and Non Hodgkin's Lymphoma (NHL) in various stages were studied. Tc-99m Tetrofosmin (Tf) (Myoview-source Nycomed Amersham Pic, England was injected intravenously and static images of the involved site were taken at 5 minutes, one hour and again at 24 hours. Static images of the skull, chest, axillae, abdomen and pelvis were acquired at 30 minutes. Subsequently 5 patients were studied with Ga-67. The images were compared. Results: The total number of clinically involved sites in 13 patients were 75 and 99m Tc-Tf uptake was seen in 16 sites only (20%). Of the 5 patients who had both the studies the total number of clinically involved sites were 25. 99m Tc-Tf uptake was seen in 8 sites whereas Ga-67 uptake was seen in 11 sites (44%). 99m Tc-Tf uptake in abdominal sites was masked by hepatobiliary excretion Conclusion: Ga-67 is superior to 99m Tc-Tf in imaging lymphoma.

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