Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1584 Print this page  Email this page Small font size Default font size Increase font size
Year : 2006  |  Volume : 21  |  Issue : 2  |  Page : 36-40

Comparison of Nitrate Augmented 99mTc-Sestamibi Infusion with Nitrate Augmented 99mTc-Sestamibi Bolus Injection for the Detection of Myocardial Viability

Department of Nuclear Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India

Correspondence Address:
R V Parameswaran
Department of Nuclear Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Aim: It has been stated that nitrate augmented 99m Tc-Sestamibi bolus injection is almost comparable to 24- hour reinjection of Tl-201 for the detection of myocardial viability. This study was aimed to see if nitrateaugmented infusion injection of 99m Tc-Sestamibi can reveal more areas of viable myocardium as compared to the standard stress rest protocol of 99m Tc-Sestamibi and nitrate-augmentation. Materials & Methods: 25 patients (all men) with a mean age of 42.72 yrs (age ranging from 28-57 yrs) with a recent history of myocardial infarction (3 weeks to 6 months) were included in the study. A routine stress - rest myocardial perfusion scan with 99m Tc-Sestamibi was performed on these subjects. The rest study was augmented with 10 mg of nitroglycerin sublingually. These subjects were given the same dose of nitroglycerin and 99m Tc-Sestamibi two days later. 99mTc-Sestamibi was given as an infusion over a period of 45 minutes and images were obtained after one hour. 17 segment myocardial model was taken for analysis and a total of 425 segments were analyzed out of which 176 segments were for viability evaluation. Results: In resting images obtained with MIBI bolus injection, there was improvement in 17 segments (9.6%) when compared to the post stress images and in images obtained after infusion, there was improvement in 34 assessed for viability segments (19.3%). In the remaining segments, there was improvement in 48 segments (19.27%) in the images obtained with MIBI bolus injection and improvement in 85 segments (34.13%) in the images obtained with MIBI infusion. Conclusion: This study shows that nitrate augmented MIBI infusion is helpful in detecting more areas of viable myocardium when compared to the standard resting study following bolus injection.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded113    
    Comments [Add]    

Recommend this journal