Indian Journal of Nuclear Medicine
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Year : 2011  |  Volume : 26  |  Issue : 4  |  Page : 208-210

False positive localisation of C-11 methionine in a colloid nodule

1 Division of PET Imaging, Molecular Imaging and Research Centre, , New Delhi, India
2 Lok Nayak Jai Prakash Narayan Hospital, Maulana Azad Medical College, New Delhi, India

Correspondence Address:
Madhavi Tripathi
Room No: 201, Second floor, Division of Clinical PET, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi - 54
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-3919.106719

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A 45-year-old female diagnosed with carcinoma of the left breast on histopathological examination underwent both 18 F-flourodeoxyglucose (FDG) and 11C-methionine (MET) positron emission tomography/computed tomography (PET/CT) as part of a protocol comparing the utility of these tracers for predicting a response to neoadjuvant chemotherapy in breast carcinoma. Abnormal FDG and MET accumulation was noted in the left breast primary, left axillary lymph nodes, and also in a well-defined nodule present in the left lobe of the thyroid gland. Keeping in mind the possibility of thyroid neoplasm/metastasis, the patient was referred for fine needle aspiration cytology (FNAC) from the thyroid nodule that revealed features of a simple colloid nodule. Focal thyroid lesions incidentally found on 18 F-FDG PET/CT have a high risk of thyroid malignancy. Non-specific accumulation of FDG in thyroid adenomas is also known. This case highlights a potential cause for false positive on C-11 MET PET/CT in colloid adenomas, which should be kept in mind while using this tracer for oncological indications.

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