Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1861 Print this page  Email this page Small font size Default font size Increase font size
Year : 2012  |  Volume : 27  |  Issue : 3  |  Page : 164-171

Diagnosis of bone infection by complementary role of technetium-99m MDP and technetium-99m hexamethylpropylene-amineoxime-leukocytes

1 Department of Orthopedic, Faculty of Medicine, Taif University, Taif, Saudi Arabia
2 Department of Medical Imaging, Faculty of Medicine, Taif University, Taif, Saudi Arabia
3 Nuclear medicine department, Al-Hada Armed Force Hospital, Taif, Saudi Arabia

Correspondence Address:
Khaled El-Saban
Department of Medical Imaging, Faculty of Medicine, Taif University, Taif
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-3919.112721

Rights and Permissions

Purpose: Valuate complementary role of 99m Tc-MDP bone scan and 99m Technetium hexamethylpropylene-amineoxime ( 99m Tc-HMPAO) labeled leukocyte scintigraphy in diagnosis of bone infection. Patients and Methods: Ninety one sites suspected to have bone infection were divided in to two groups: Group I 49 sites with current endo-prothesis; and group II 42 sites with no prosthesis. All patients were subjected to serial images of 99m Tc-HMPAO labeled leukocyte ( 99m Tc-white blood cells (WBCs)), triple phase bone scan ( 99m Tc-MDP) and plain X-ray, in addition to clinical and bacteriological assessment, together with follow-up. Results: The overall sensitivity (Sn) was found to be 34.9%, 95.4%, and 86% for plain X-ray, 99m Tc-MDP, and 99m Tc-WBCs respectively. Concerning specificity (Sp) was found to be 47.9%, 45.8%, and 91.7% respectively for the three imaging modalities. 99m Tc-WBCs showed better Sn, Sp, and accuracy in group I (95%, 93.1% and 93.9%, respectively) compared to 40%, 41.4%, and 40.8% for plain X-ray and 90%, 62%, and 73.5% respectively for 99m Tc-MDP. On the other hand, 99m Tc-MDP proved to have best Sn 100% versus 78.3% and 30.4% for 99m Tc-WBCs and plain X-ray respectively. Yet, Sp and accuracy was found to best for 99m Tc-WBCs (89.5% and 83.3% respectively) compared to 57.9% and 42.9% for plain X-ray and 21.1% and 64.3% for 99m Tc-MDP. Conclusion: Combined imaging with 99m Tc-WBCs and 99m Tc-MDP proved to be effective in early detection of bone infection in the presence or absence of prosthesis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded120    
    Comments [Add]    

Recommend this journal