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Year : 2015  |  Volume : 30  |  Issue : 1  |  Page : 1-8

Use of 99m-technetium-glucoheptonate as a tracer for brain tumor imaging: An overview of its strengths and pitfalls

1 Department of Nuclear Medicine, Medical College Kolkata, Kolkata, West Bengal, India
2 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Amburanjan Santra
D 4E, Souraniloy Housing Complex, No. 1, Kailash Ghosh Road, Kolkata - 700 008, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-3919.147525

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Brain tumors represent a vexing clinical problem in oncology due to their increasing incidence, difficulties in treatment and high rates of recurrence. It is especially challenging to evaluate the posttreatment disease status because differentiation of recurrence from treatment-induced changes (radiation necrosis) is not possible with the use of magnetic resonance imaging, the most commonly used imaging method in this setting. Various functional imaging methods, including positron emission tomography and single photon emission computed tomography (SPECT) have been employed in this context. SPECT with 99m-technetium (99mTc)-glucoheptonate (GHA) has shown promising results for differentiation of recurrent brain tumor from radiation necrosis. In this review, we have discussed in details the basics of 99mTc-GHA SPECT imaging in brain tumor along with the available literature in this regard.

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