|Year : 2015 | Volume
| Issue : 1 | Page : 31-38
Potential role of 18 F-2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography imaging in patients presenting with generalized lymphadenopathy
Sellam Karunanithi, Ganesh Kumar, Punit Sharma, Chandrasekhar Bal, Rakesh Kumar
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
|Date of Web Publication||23-Dec-2014|
Dr. Rakesh Kumar
E-81, Ansari Nagar (East), All India Institute of Medical Sciences Campus, New Delhi - 110 029
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Generalized lymphadenopathy is a common and often vexing clinical problem caused by various inflammatory, infective and malignant diseases. We aimed to review briefly and highlight the potential role of 18 F-2-fluoro-2-deoxy-glucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) in such patients. 18 F-FDG PET/CT can play an important role in the management of generalized lymphadenopathy. It can help in making an etiological diagnosis; can detect extranodal sites of involvement and employed for monitoring response to therapy.
Keywords: 18 F-2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography, generalized lymphadenopathy, lymphoma, sarcoidosis, tuberculosis
|How to cite this article:|
Karunanithi S, Kumar G, Sharma P, Bal C, Kumar R. Potential role of 18 F-2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography imaging in patients presenting with generalized lymphadenopathy. Indian J Nucl Med 2015;30:31-8
|How to cite this URL:|
Karunanithi S, Kumar G, Sharma P, Bal C, Kumar R. Potential role of 18 F-2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography imaging in patients presenting with generalized lymphadenopathy. Indian J Nucl Med [serial online] 2015 [cited 2022 Jan 26];30:31-8. Available from: https://www.ijnm.in/text.asp?2015/30/1/31/147532
| Introduction|| |
Positron emission tomography (PET) using 18 F-2-fluoro- 2-deoxy-glucose ( 18 F-FDG) has gradually evolved in its application through the years since its conception, especially with the added dimension of anatomic correlation brought about with the fusion of computed tomography (CT) with PET. Furthermore, the list of indications for 18 F-FDG PET/CT imaging has expanded from oncology to now include even a multitude of nononcological diagnoses. In this aspect, 18 F-FDG PET/CT can play an important role in the diagnosis and management of clinical entities like generalized lymphadenopathy that are routinely encountered in clinical practice.
Generalized lymphadenopathy is defined as an enlargement of more than two non-contiguous lymph node groups and can be caused by a wide range of conditions ranging from benign self-limited diseases to the most aggressive malignancies. The list of etiologies for generalized lymphadenopathy itself can be quite elaborate and exhaustive. However, in this review, we have attempted to discuss the most common as well as a few interesting and noteworthy causes of generalized lymphadenopathy and the role of 18 F-FDG PET/CT in the diagnosis and management of each of these pathological conditions. An attempt has also been made to highlight the pattern of lymphadenopathy and other imaging features on 18 F-FDG PET/CT that can be pointer to the cause of lymphadenopathy.
Rosai Dorfman disease
This condition was initially described as giant cell sinus reticulosis by John Smith in 1947, and later renamed by Rosai and Dorfman as sinus histiocytosis with massive lymphadenopathy.  Although no specific etiological agent has been demonstrated, the morphological features suggest a greatly exaggerated reactive process. The clinical presentation is, usually, that of a young adult presenting with massive, painless cervical lymphadenopathy. Extranodal involvement has been observed in 25-43% of patients  especially the upper respiratory tract, salivary glands, orbit, testis and skin. The natural history is that of gradual, spontaneous resolution, although surgery has been used for relief from compressive symptoms.  Although the clinical presentation is often typical as described above, atypical presentations are not uncommon. Cases have been described in the literature about utility of 18 F-FDG PET/CT in many atypical patients with isolated intracranial,  pure cutaneous,  bone involvement  and the likes. Rosai Dorfman disease (RDD) can present as massive generalized lymphadenopathy and can mimic lymphoma on 18 F-FDG PET/CT. Usually in RDD the involved lymph nodes reveal intense central 18 F-FDG uptake with reduced uptake in the periphery [Figure 1]. This can provide a diagnostic clue as lymphoma shows homogenous intense uptake and tuberculosis (TB) shows central necrosis.  Being a sensitive and whole-body imaging technique, 18 F-FDG PET/CT has the potential to be used for assessment of disease burden, prognostication, treatment planning, and response assessment in RDD. 
|Figure 1: (a-c) A 58-year-old female with histologically confirmed Rosai Dorfman disease. Maximum intensity projection positron emission tomography (PET) image (a) and trans-axial PET/computed tomography images of neck (b), and abdomen (c), revealed multiple enlarged 18F-2-fluoro-2-deoxy-glucose avid bilateral cervical, axillary, retroperitoneal and mesenteric lymph nodes (arrows) along with splenic lesion (broken arrow)|
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One of the causes of nonneoplastic lymphadenopathy, this condition has been known historically by many names such as "giant lymph node hyperplasia," "angiomatous lymphoid hyperplasia," "angiofollicular mediastinal lymph node hyperplasia," etc., Although the original case was described by Castleman and Towne as a mediastinal mass resembling a thymoma, lymph node groups in the neck, axilla, mesentery, and pelvis have been known to be involved in this disease.  Also, involvement of other sites such as the pancreas, adrenal and the retroperitoneum has also been reported.  Two morphological types are identified, namely unicentric and multicentric; the unicentric variant can be often treated with surgery, whereas the multicentric disease requires a multi-modality approach including chemotherapy, steroids, antiviral therapy and antiproliferative regimens as only surgery cannot be used for curative purpose. The pathogenesis, although unknown, points toward a faulty immune regulation resulting in excessive B-cell and plasma cell proliferation. The association of this disease with human immunodeficiency virus (HIV) and Kaposi sarcoma herpes virus have been well-documented, typically for the multicentric variant. 
Castleman's disease (CD) is a benign lymphoproliferative disease, which, usually, shows hypermetabolism on 18 F-FDG PET/CT [Figure 2]. Multicentric form of CD can present with multiple lymph nodes with 18 F-FDG avidity on whole body PET/CT and can mimic lymphoma.  The confirmative diagnosis is made by pathologic examination. Currently, multicentricity of the disease is the most significant prognostic factor in CD.  Patients with unicentric CD, which is more common, can be cured with a good prognosis,  whereas multicentric CD is more aggressive and demonstrates poorer clinical course with potential for malignant transformation.  18 F-FDG uptake has been found to have a significant correlation with multicentricity and presence of clinical manifestations.  For the diagnosis of CD lesions, 18 F-FDG PET/CT is more sensitive than contrast-enhanced CT,  as lymph nodes without significant enlargement may be missed on CT. 18 F-FDG uptake on PET/CT can be a surrogate imaging marker for severity or prognosis of CD. 18 F-FDG PET/CT has a useful role in the management of HIV-associated CD in selecting appropriate sites for biopsy and in staging and monitoring disease. 
|Figure 2: (a-c) An 18-year-old male with Castleman's disease. Maximum intensity projection positron emission tomography (PET) image (a) revealed multiple enlarged 18F-2-fluoro-2-deoxy-glucose avid cervical, axillary, mediastinal, retroperitoneal and inguinal lymph nodes (arrows). Transaxial PET/computed tomography images demonstrating splenic (b, arrowhead) and bone marrow (c, broken arrow) involvement|
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Sarcoidosis is multisystem granulomatous disease characterized by the formation of non caseating granuloma in the affected tissues.  Yet to have a definitively proven causative agent, the disease is characterized by various patterns of presentation. The disease primarily affects the pulmonary and lymphatic systems and hence a patient of sarcoidosis presenting with generalized lymphadenopathy is not uncommon. Extra-pulmonary manifestations can be seen in up to 50% of patients,  with many presenting with mediastinal/intra-thoracic lymphadenopathy. Though hilar/mediastinal lymph nodes are mainly involved, involvement of other groups of lymph nodes (such as the abdominal, pelvic and inguinal lymph nodes) as well as spleen is not uncommon, especially after antineoplastic therapy for any concurrent cancers.
18 F-2-fluoro-2-deoxy-glucose-positron emission tomography/computed tomography can play a significant role in the diagnosis and management of sarcoidosis. It can improve the accuracy for diagnosis of extra-pulmonary involvement, specify the respective contributions of active and fibrotic components of lesions, guide the selection of the biopsy site, provide prognostic information and guide therapeutic management,  The lymph nodal involvement in sarcoidosis on 18 F-FDG PET/CT is invariably symmetrical. Predominant involvement of mediastinal lymph nodes with high 18 F-FDG avidity (typically called the "lambda sign") can provide a diagnostic clue [Figure 3]. Furthermore, a study by Aide et al.  suggested that in cases of their coincidence, an early 18 F-FDG PET/CT can be helpful in differentiating sarcoidosis from cancer recurrences through a trial of systemic corticosteroids to which patients of sarcoidosis respond well.
|Figure 3: (a-c) A 31-year-old female with sarcoidosis, for baseline evaluation. Maximum intensity projection positron emission tomography (PET) image (a) revealed multiple enlarged 18F-2-fluoro-2-deoxy-glucose (18F-FDG) avid cervical, axillary, mediastinal, portal, retroperitoneal and inguinal lymph nodes (broken arrows). Note is made of the "lambda sign" due to typical symmetrical 18F-FDG avid mediastinal lymph nodes involvement (a, bold arrows) transaxial PET/computed tomography images demonstrating lung (b, arrows) and splenic (c, arrows) involvement|
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Tagged with the infamy of being one of the most prevalent infectious diseases in the world, TB can have a broad array of clinical presentations. Granulomatous lymphadenopathy caused by TB is one of the leading causes of generalized lymphadenopathy in adults. While the primary site of infection in TB is the lungs, in up to 15% of cases an extrapulmonary site may produce the first symptoms; and lymph nodes constitute the most common extrapulmonary presentation in TB. The peak incidence age is between 20 and 40 years,  with majority of affected patients presenting with cervical lymph nodes and a fair proportion of them harboring the disease at >1 lymph nodal site.  Transient flares of lymphadenitis tend to occur in patients during initiation of antitubercular therapy and in HIV affected patients who are started on antiretroviral therapy,  which has to be kept in mind in case such patients undergo 18 F-FDG PET/CT. Also, the concurrent presence of TB lymphadenitis in the setting of any malignancy  might lead to faulty staging of the malignancy and can have a significant impact on further management of the patient. When compared with CT, 18 F-FDG PET/CT imaging has been found to be significantly more efficient for the identification of sites of involvement, especially extra pulmonary TB.  On 18 F-FDG PET/CT, associated changes in lungs, areas of calcification and lesions with central necrosis may provide some diagnostic clues favoring tuberculous etiology in patients presenting with generalized lymphadenopathy [Figure 4]. However, histopathology remains the gold standard. 18 F-FDG PET/CT can demonstrate lesion extent, serve as a guide for biopsy with aspiration for culture, assist surgery planning and contribute to follow-up. 18 F-FDG PET/CT imaging can also help in the evaluation of therapeutic response in TB patients.  Early response evaluation in TB, especially in the setting of suspected multi-drug resistant TB is a strong indication where PET scores over culture with PET as early as 3-4 weeks after start of treatment being able to demonstrate response to no response.
|Figure 4: (a-c) A 21-year-old female, known case of tuberculosis. Maximum intensity projection positron emission tomography (PET) image (a) revealed multiple enlarged 18F-2-fluoro-2-deoxy-glucose (18F-FDG) avid cervical, axillary, mediastinal, mesenteric, retroperitoneal and inguinal lymph nodes (arrows) transaxial PET/computed tomography (CT) images of thorax (b) 18F-FDG avid nodal (arrow) involvement. Note the calcification in mediastinal nodes (broken arrow). Transaxial PET/CT image of the lungs (c) 18F-FDG avid pulmonary involvement|
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Actinomycosis is caused most commonly by the anaerobic bacterium Actinomyces israelii. It can affect any organ in the body as a chronic suppurative infection, but cervico-facial, abdomino-pelvic, and the thoracic are the three most common types in the order of incidence.  However, unlike the case with other chronic infections, the immunocompromised status of the patient does not seem to increase its infection rate.  The abdomino-pelvic and thoracic types have a tendency to cause abdominal and mediastinal lymphadenopathy, respectively, with involvement of lymph node groups on the other side of the diaphragm as the disease progresses [Figure 5]. The thoracic disease, which initially colonizes the lung parenchyma or the airways, is notorious for its tendency to spread to chest wall with involvement of ribs and vertebrae,  owing to the organism's ability to produce proteolytic enzymes. The abdomino-pelvic disease may simulate the natural history of lymphoma  or a malignant process, masquerading as an intra-abdominal mass with constitutional symptoms and a prolonged course. A few cases of 18 F-FDG PET/CT appearance of actinomycosis have been documented. 
|Figure 5: (a-d) A 27-year-old male who presented with generalized lymphadenopathy. Transaxial positron emission tomography/computed tomography images (a-d) revealed mildly 18F-2-fluoro-2-deoxy-glucose avid bilateral cervical, axillary, mediastinal and abdominal lymph nodes (arrows). Biopsy from the lymph node was positive for actinomycosis|
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Histoplasmosis, a systemic mycosis, is caused by the fungus Histoplasma capsulatum. The clinical spectrum of the disease ranges from an asymptomatic infection, an acute or chronic pulmonary infection, mediastinal fibrosis or disseminated histoplasmosis.  A chronic infection caused by the organism often results in a diagnostic dilemma due to the resemblance with other chronic diseases. The clinical and imaging features of chronic pulmonary histoplasmosis resemble reactivation of pulmonary TB (with hilar or mediastinal lymphadenopathy and diffuse reticulonodular infiltrates/cavitation in the lungs).  On the other hand, chronic disseminated histoplasmosis is, usually, seen affecting the immunocompromised patients and can involve multiple organs and systems. In immunocompromised state, patients with opportunistic fungal infection can present with generalized lymphadenopathy. Mediastinal lymphadenopathy can lead to troublesome compression of structures such as esophagus, superior vena cava and the airways;  however, the pulmonary parenchyma is, usually, unaffected in the disseminated form of the disease. Rarely histoplasmosis can present with oropharyngeal involvement in immunocompromised patients with disseminated disease in the form of generalized lymphadenopathy.  On PET/CT, lesions of the histoplasmosis are, usually, 18 F-FDG avid. Since, 18 F-FDG is a highly sensitive but not specific radiotracer for infection imaging, histoplasmosis is likely to be a cause for a false-positive examination, reducing the specificity of 18 F-FDG PET/CT for the detection and staging of lung carcinoma. 
Hodgkin's lymphoma is one of the malignancies on which an immense amount of research has been and is still being done owing to its curability. In fact, the current literature suggests that with appropriate treatment, 65-90% of the patients can be rendered disease-free, depending on the clinical type and the stage.  Associated with a bimodal age distribution, the disease, usually, presents with a painless superficial lymphadenopathy with a contiguous spread by lymphatic network. Untreated cases lead to extranodal and visceral involvement, including bone marrow, spleen and liver along with generalized lymphadenopathy [Figure 6]a and b. 18 F-FDG PET/CT has a central role in the management of Hodgkin lymphoma. It has been shown to have a higher sensitivity compared with conventional imaging in staging and assessment of treatment response.  Although bone marrow involvement is uncommon, its identification on PET/CT has important clinical implications by identifying a site for marrow biopsy as well as accurate staging. A recent study by Ömür et al.  has shown that in cases with nodal and extranodal involvement, there was a high positive correlation (r = 0.67) between the SUVmax values of the highest 18 F-FDG accumulating lymph nodes and the involvement of extranodal sites.
|Figure 6: (a-f) A 38-year-old male with Hodgkin lymphoma (a and b), revealing 18F-2-fluoro-2-deoxy-glucose (18F-FDG) avid cervical, mediastinal, abdominal and inguinal lymph nodes, (a) apart from splenic (b, arrow) and liver (b, broken arrow) involvement. 34-year-old female with DLBCL (c and d), revealing 18F-FDG avid enlarged cervical, axillary, mediastinal, abdominal and inguinal lymph nodes, apart from splenic (c, broken arrow) and bone marrow (d, arrow) involvement. 73-year-old female with B-cell SLL (e and f), revealing mildly 18F-FDG-avid generalized lymph node involvement (arrows) with loss of normal architecture (f, arrows)|
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High grade B-cell non-Hodgkin's lymphoma
High-grade non-Hodgkin's lymphomas (NHL) follow a more aggressive course and carry a poorer prognosis. Although there are 50 distinct subtypes of NHL, as per the Revised European-American Lymphoma classification, the following subtypes are labeled as high grade: Mantle cell lymphoma, follicular center lymphoma, grade III, diffuse large B-cell lymphoma (DLBCL) and primary mediastinal large B-cell lymphoma.  The affected lymph node groups in these subtypes, usually, tend to be intensely 18 F-FDG-avid on PET/CT and tend to have earlier involvement of extranodal sites such as the spleen and bone marrow.  In a patient presenting with generalized lymphadenopathy, intensely 18 F-FDG avid lymph nodes along with involvement of bone marrow and/or spleen on PET/CT may provide a clue to high grade lymphomatous etiology [Figure 6]c and d. Necrosis or calcification in the lymph nodes is almost never seen on baseline PET/CT but can be seen post chemotherapy. A recent study by Khan et al.  showed that 18 F-FDG PET/CT has a sensitivity of 94% in identifying bone marrow involvement in patients affected with DLBCL, when compared to 40% with bone marrow biopsy and thus, may be used as an effective diagnostic tool in identifying bone marrow involvement in aggressive lymphoma. Like in any lymphoma, PET/CT has a two-prong function in management of these aggressive lymphomas; while an interim PET/CT can be helpful in assessment and identification of early treatment response, an end-of-treatment PET/CT can be used to assess remission.  However, the literature is still inconclusive as to whether interim PET/CT should be included in standard therapy guidelines in the management of this group of disorders. 
Low grade B-cell non-Hodgkin's lymphoma
The most common types of NHL that are usually classified as low grade/indolent lymphomas include the B-cell small lymphocytic lymphoma (SLL/CLL), mucosa-associated lymphoid tissue marginal zone lymphoma and the indolent form (Grade I) follicular lymphoma.  Enlarged lymph nodes with low 18 F-FDG avidity on PET/CT imaging may suggest a low-grade lymphoma [Figure 6]e and f. 18 F-FDG PET/CT is sparsely used in the management of these lymphomas through their course in terms of staging, monitoring of therapy and follow-up. Another important role of PET/CT is the identification of infections and second malignancies in this group of lymphomas, particularly SLL.  Also, up to 5-10% of patient affected with indolent lymphomas transform to one of the aggressive, high-grade lymphomas and that generally heralds a poor prognosis.  18 F-FDG PET/CT can be of great importance in this regard by demonstrating prominent increase in the 18 F-FDG uptake in transformed lymphoma.
Many studies have evaluated the role of PET/CT in the diagnosis and management of low-grade lymphomas in multiple possible dimensions. A study by Conte et al.  done on a large cohort of patients affected with CLL showed that the patients with high 18 F-FDG avidity tend to have poorer survival rates than those with low 18 F-FDG avid lesions on PET/CT. Also, PET/CT helps in identifying unique sites of extranodal involvement in grade 1 follicular lymphoma.
T-cell non-Hodgkin's lymphoma
T-cell lymphomas contribute to approximately 10-15% of all lymphoid malignancies.  T-cell lymphomas are considered as high-grade NHL. A fair proportion of patients present with concurrent nodal and extranodal disease, the commonest extranodal site being bone marrow and spleen. Also, the nodal disease tends to involve nodal groups on either sides of the diaphragm [Figure 7]a. Many of the T-cell lymphoma subtypes have a tendency to present with multiple extranodal site involvement with some subtypes showing up to 100% probability of extranodal disease; so majority of patients have poor risk disease with frequent relapses and unfavorable outcome. 
|Figure 7: (a and b) A 57-year-old male with CD3+ peripheral T-cell lymphoma. Maximum intensity projection (MIP) positron emission tomography (PET) image (a) revealing 18F-2-fluoro-2-deoxy-glucose (18F-FDG) avid bilateral multiple cervical, axillary, mediastinal, abdomino-pelvic and inguinal lymph nodes (broken arrows), 27-year-old male with angiolymphoblastic T-cell lymphoma. MIP PET image (b) revealing mild to moderately 18F-FDG avid bilateral multiple cervical, axillary, mediastinal, abdomino-pelvic and inguinal lymph nodes (arrows)|
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Many studies have evaluated the role of 18 F-FDG PET/CT in the management of T-cell lymphomas. In an analysis made by Casulo et al.  to assess the role of 18 F-FDG PET for staging of peripheral T-cell lymphoma, the study group found that the 18 F-FDG PET/CT can identify additional sites of disease involvement. The study also showed that an interim PET/CT can help in predicting the progression-free survival in this group of patients. Another study by Cheng et al.  suggested that 18 F-FDG PET/CT plays a role in restaging, evaluation of outcome and treatment planning of T-cell lymphomas.
Initially described in the medical literature as angioimmunoblastic lymphadenopathy, this entity was thought to be a hyperimmune lymphocyte pathology mimicking Hodgkin's lymphoma.  This disease has since undergone a change in nomenclature and now has been renamed as angioimmunoblastic T-cell lymphoma owing to an aggressive course and poor mean survival period. Apart from lymphadenopathy, other findings include constitutional symptoms, hepatosplenomegaly and autoimmune phenomena in elderly patients, typically in their sixth or seventh decade of life.  The clinicopathological features of this disease qualify it as a subtype of peripheral T-cell lymphomas;  however, there is considerable overlap among the various subtypes and hence, the exact classification is still evolving. Irrespective of these factors, this disease carries a poor outcome with a median survival of about 3 years.  Not many studies have been done to understand the role of 18 F-FDG PET/CT in the management of this disease, perhaps owing to its rarity and its aggressive course with shortened survival. Such patients can present with 18 F-FDG avid generalized lymphadenopathy on PET/CT [Figure 7]b. More studies in the future assessing the role of 18 F-FDG PET/CT in this entity might offer a better insight in understanding the disease biology and management.
Any malignancy which spreads through lymphatic route can present with generalized lymphadenopathy at an advanced stage; such as carcinoma of breast, lung, digestive tract, melanomas, ovary [Figure 8] and head and neck cancers. Also, lymph nodes are the most common site of metastases encountered in the evaluation of carcinoma of unknown primary.  Apart from the changes in their architecture on anatomic imaging, many studies have shown that lymph nodes from metastatic deposit tend to show a higher value of their SUV parameters as against their benign counterparts;  however this does not hold true in a significant minority of cases. Although certain cancers can classically present with generalized lymph node enlargement, some cases have been described to arise from such primary sites which are not known to cause isolated widespread nodal dissemination at initial presentation. One such case of prostatic adenocarcinoma has been described by Joshi and Lele  where an elderly male presented with lymphadenopathy without any urinary symptoms; the case clinically was mimicking lymphoma. However, the 18 F-FDG PET/CT done in this patient helped in identifying the primary, in staging and initiation of appropriate treatment for his actual condition. Also, such situations have been encountered where not the malignancy per se, but even the treatment modalities employed in its management have caused generalized lymphadenopathy and led to diagnostic ambiguities. One such case has been described by Yune et al.  where a person with malignant melanoma developed generalized lymphadenopathy after he underwent interferon therapy. Although 18 F-FDG PET/CT was not helpful in distinguishing the reactive nodal enlargement, this case brings to fore a pitfall of PET/CT and warns an interpreting physician to be aware of such possibilities.
|Figure 8: (a-c) A 67-year-old female with biopsy proven ovarian carcinoma. Maximum intensity projection positron emission tomography (PET) image (a) and transaxial PET/computed tomography images (b and c) revealed multiple enlarged 18F-2-fluoro-2-deoxy-glucose avid cervical, axillary, mediastinal, retroperitoneal, mesenteric and pelvic metastatic lymph nodes (arrows)|
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| Conclusions|| |
Generalized lymphadenopathy is a relatively common clinical problem and can be caused by a wide array of inflammatory, infective and malignant pathologies. Due to its ability to detect upregulated glucose metabolism, 18 F-FDG PET/CT can be used for evaluation of these diseases presenting with generalized lymphadenopathy. It can help in narrowing the differential diagnoses, detect extranodal involvement and be useful for post therapy monitoring in such patients. Familiarity of the nuclear radiologist with the causes and 18 F-FDG PET/CT patterns of generalized lymphadenopathy are essential for optimum utilization in this clinical setting.
| References|| |
Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity. Semin Diagn Pathol 1990;7:19-73.
Karunanithi S, Singh H, Sharma P, Naswa N, Kumar R 18F-FDG PET/CT imaging features of Rosai Dorfman disease: A rare cause of massive generalized lymphadenopathy. Clin Nucl Med 2014;39:268-9.
Raveenthiran V, Dhanalakshmi M, Hayavadana Rao PV, Viswanathan P. Rosai-Dorfman disease: Report of a 3-year-old girl with critical review of treatment options. Eur J Pediatr Surg 2003;13:350-4.
Deshayes E, Le Berre JP, Jouanneau E, Vasiljevic A, Raverot G, Seve P 18F-FDG PET/CT findings in a patient with isolated intracranial Rosai-Dorfman disease. Clin Nucl Med 2013;38:e50-2.
Huang JY, Lu CC, Hsiao CH, Tzen KY. FDG PET/CT findings in purely cutaneous Rosai-Dorfman disease. Clin Nucl Med 2011;36:e13-5.
Tsang JS, Anthony MP, Wong MP, Wong CS. The use of FDG-PET/CT in extranodal Rosai-Dorfman disease of bone. Skeletal Radiol 2012;41:715-7.
Perera AS, Keleher AJ, Nath M. Rosai-Dorfman disease presenting as a male breast mass. Am Surg 2007;73:294-5.
Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. Korean J Hematol 2012;47:163-77.
Elboga U, Narin Y, Urhan M, Sahin E. FDG PET/CT appearance of multicentric Castleman's disease mimicking lymphoma. Rev Esp Med Nucl Imagen Mol 2012;31:142-4.
Shin DY, Jeon YK, Hong YS, Kim TM, Lee SH, Kim DW, et al.
Clinical dissection of multicentric Castleman disease. Leuk Lymphoma 2011;52:1517-22.
Enomoto K, Nakamichi I, Hamada K, Inoue A, Higuchi I, Sekimoto M, et al.
Unicentric and multicentric Castleman's disease. Br J Radiol 2007;80:e24-6.
Lee ES, Paeng JC, Park CM, Chang W, Lee WW, Kang KW, et al.
Metabolic characteristics of Castleman disease on 18F-FDG PET in relation to clinical implication. Clin Nucl Med 2013;38:339-42.
Barker R, Kazmi F, Stebbing J, Ngan S, Chinn R, Nelson M, et al.
FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging 2009;36:648-52.
Jain V, Hasselquist S, Delaney MD. PET scanning in sarcoidosis. Ann N Y Acad Sci 2011;1228:46-58.
Soussan M, Augier A, Brillet PY, Weinmann P, Valeyre D. Functional imaging in extrapulmonary sarcoidosis: FDG-PET/CT and MR features. Clin Nucl Med 2014;39:e146-59.
Aide N, Allouache D, Ollivier Y, de Raucourt S, Switsers O, Bardet S. Early 2'-deoxy-2'- [18F] fluoro-D-glucose PET metabolic response after corticosteroid therapy to differentiate cancer from sarcoidosis and sarcoid-like lesions. Mol Imaging Biol 2009;11:224-8.
Perlman DC, D'Amico R, Salomon N. Mycobacterial Infections of the head and neck. Curr Infect Dis Rep 2001;3:233-41.
Geldmacher H, Taube C, Kroeger C, Magnussen H, Kirsten DK. Assessment of lymph node tuberculosis in northern Germany: A clinical review. Chest 2002;121:1177-82.
Kim HW, Choi BW, Won KS, Zeon SK. Cervical tuberculous lymphadenitis mimicking distant lymph node metastasis on F-18 FDG PET/CT in a patient with gastric carcinoid tumor. Clin Nucl Med 2009;34:946-7.
Sathekge M, Maes A, Van de Wiele C. FDG-PET imaging in HIV infection and tuberculosis. Semin Nucl Med 2013;43:349-66.
Demura Y, Tsuchida T, Uesaka D, Umeda Y, Morikawa M, Ameshima S, et al.
Usefulness of 18F-fluorodeoxyglucose positron emission tomography for diagnosing disease activity and monitoring therapeutic response in patients with pulmonary mycobacteriosis. Eur J Nucl Med Mol Imaging 2009;36:632-9.
Han JY, Lee KN, Lee JK, Kim YH, Choi SJ, Jeong YJ, et al.
An overview of thoracic actinomycosis: CT features. Insights Imaging 2013;4:245-52.
Bartlett AH, Rivera AL, Krishnamurthy R, Baker CJ. Thoracic actinomycosis in children: Case report and review of the literature. Pediatr Infect Dis J 2008;27:165-9.
Webb WR, Sagel SS. Actinomycosis involving the chest wall: CT findings. AJR Am J Roentgenol 1982;139:1007-9.
Amrikachi M, Krishnan B, Finch CJ, Shahab I. Actinomyces and actinobacillus actinomycetemcomitans-actinomyces-associated lymphadenopathy mimicking lymphoma. Arch Pathol Lab Med 2000;124:1502-5.
Mok GS, Choi FP, Chu WC. Actinomycosis imitating parotid cancer with metastatic lymph nodes in FDG PET/CT. Clin Nucl Med 2011;36:309-10.
Mansoor CA, Bhargavan PV, Rajanish R, Nair LR. Disseminated histoplasmosis. Indian J Orthop 2013;47:639-42.
Aidé MA. Chapter 4 - Histoplasmosis. J Bras Pneumol 2009;35:1145-51.
Antonello VS, Zaltron VF, Vial M, Oliveira FM, Severo LC. Oropharyngeal histoplasmosis: Report of eleven cases and review of the literature. Rev Soc Bras Med Trop 2011;44:26-9.
Croft DR, Trapp J, Kernstine K, Kirchner P, Mullan B, Galvin J, et al.
FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence. Lung Cancer 2002;36:297-301.
Küppers R, Engert A, Hansmann ML. Hodgkin lymphoma. J Clin Invest 2012;122:3439-47.
Hutchings M, Barrington SF. PET/CT for therapy response assessment in lymphoma. J Nucl Med 2009;50 Suppl 1:21S-30.
Ömür Ö, Baran Y, Oral A, Ceylan Y. Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma. Diagn Interv Radiol 2014;20:185-92.
Tohda S. Overview of lymphoid neoplasms in the fourth edition of the WHO classification. Rinsho Byori 2012;60:560-4.
Hosein PJ, Lossos IS. The evolving role of F-FDG PET scans in patients with aggressive non-Hodgkin's lymphoma. European J Clin Med Oncol 2010;2:131-38.
Khan AB, Barrington SF, Mikhaeel NG, Hunt AA, Cameron L, Morris T, et al.
PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement. Blood 2013;122:61-7.
Barrington SF, Mikhaeel NG. When should FDG-PET be used in the modern management of lymphoma? Br J Haematol 2014;164:315-28.
Yang DH, Min JJ, Song HC, Jeong YY, Chung WK, Bae SY, et al.
Prognostic significance of interim 18F-FDG PET/CT after three or four cycles of R-CHOP chemotherapy in the treatment of diffuse large B-cell lymphoma. Eur J Cancer 2011;47:1312-8.
Weiler-Sagie M, Bushelev O, Epelbaum R, Dann EJ, Haim N, Avivi I, et al.
(18) F-FDG avidity in lymphoma readdressed: A study of 766 patients. J Nucl Med 2010;51:25-30.
Conte MJ, Bowen DA, Wiseman GA, Rabe KG, Slager SL, Schwager SM, et al.
Use of positron emission tomography-computed tomography in the management of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma 2014;55:2079-84.
Yuen AR, Kamel OW, Halpern J, Horning SJ. Long-term survival after histologic transformation of low-grade follicular lymphoma. J Clin Oncol 1995;13:1726-33.
Armitage JO. The aggressive peripheral T-cell lymphomas: 2013. Am J Hematol 2013;88:910-8.
Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM. Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol 2004;15:1467-75.
Casulo C, Schöder H, Feeney J, Lim R, Maragulia J, Zelenetz AD, et al
. 18F-fluorodeoxyglucose positron emission tomography in the staging and prognosis of T cell lymphoma. Leuk Lymphoma 2013;54:2163-7.
Cheng J, Yang XY, Xu WG, Song XY, Dai D, Zhu YJ. Clinical significance of (18) F-FDG PET/CT evaluation of response to treatment in T-cell lymphoma. Zhonghua Xue Ye Xue Za Zhi 2012;33:16-9.
Lukes RJ, Tindle BH. Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med 1975;292:1-8.
Brown JR, Skarin AT. Clinical mimics of lymphoma. Oncologist 2004;9:406-16.
de Leval L, Gisselbrecht C, Gaulard P. Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. Br J Haematol 2010;148:673-89.
Sève P, Billotey C, Broussolle C, Dumontet C, Mackey JR. The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site. Cancer 2007;109:292-9.
Nishiyama Y, Yamamoto Y, Kimura N, Ishikawa S, Sasakawa Y, Ohkawa M. Dual-time-point FDG-PET for evaluation of lymph node metastasis in patients with non-small-cell lung cancer. Ann Nucl Med 2008;22:245-50.
Joshi P, Lele V. Prostatic adenocarcinoma masquerading as generalized lymphadenopathy and mimicking lymphoma on FDG PET/CT: Diagnosis, staging, and evaluation of therapy response by FDG PET/CT. Nephrourol Mon 2012;4:482-4.
Yune S, Jang KT, Jung SM, Kim JH, Lee J. Generalized lymphadenopathy mimicking malignant lymph node metastases after interferon-a2b therapy for melanoma. Melanoma Res 2013;23:336-9.
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