Indian Journal of Nuclear Medicine
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Year : 2015  |  Volume : 30  |  Issue : 4  |  Page : 350-351

Flip-flop phenomenon in systemic sclerosis on fluorodeoxyglucose positron emission tomography/computed tomography

1 Department of Nuclear Medicine, Marmara University, School of Medicine, Istanbul, Turkey
2 Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

Correspondence Address:
Kevser Oksuzoglu
Marmara University Pendik Research and Application Hospital, Nuclear Medicine Department, Floor -1, Fevzi Cakmak Neighborhood Muhsin Yazicioglu Street Number: 10, Ust Kaynarca, Pendik, Istanbul
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Source of Support: Nil., Conflict of Interest: None declared.

DOI: 10.4103/0972-3919.164018

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Systemic sclerosis (SSc) is a rare autoimmune disease, which may affect multiple organ systems. Fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) can demonstrate the degree and anatomical extent of involvement in the entire body and coexisting malignancies in connective tissue diseases. We present a case of SSc with an increased 18F-FDG uptake in the cutaneous and subcutaneous tissues even higher than the neighboring skeletal muscles ("flip-flop phenomenon," that is, an increased 18F-FDG uptake in the skin but a decreased 18F-FDG uptake in the skeletal muscles).

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