|Year : 2017 | Volume
| Issue : 4 | Page : 369-371
Superscan on methylene diphosphonate skeletal scintigraphy in prostatic adenocarcinoma: A common finding but rare etiology
Piyali Chatterjee, Anirban Mukherjee, Deepanjan Mitra, Amit Nautiyal, Anindya Roy
Department of Nuclear Medicine, AMRI Hospitals, Kolkata, West Bengal, India
|Date of Web Publication||12-Oct-2017|
Department of Nuclear Medicine, AMRI Hospitals, Kolkata, West Bengal
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract on skeletal scintigraphy is known as a “superscan.” Prostate cancer is the most common cause of superscan in skeletal scintigraphy due to diffuse skeletal metastases. However, prostate cancer may cause secondary renal osteodystrophy leading to metabolic superscan also. Differentiating between these two entities are important as treatment options are different. We, hereby, describe a case of prostatic adenocarcinoma presented with metabolic superscan on methylene diphosphonate skeletal scintigraphy and demonstrate the utility of single emission computed tomography-computed tomography in differentiating between two entities.
Keywords: Prostatic adenocarcinoma, renal osteodystrophy, skeletal scintigraphy, superscan
|How to cite this article:|
Chatterjee P, Mukherjee A, Mitra D, Nautiyal A, Roy A. Superscan on methylene diphosphonate skeletal scintigraphy in prostatic adenocarcinoma: A common finding but rare etiology. Indian J Nucl Med 2017;32:369-71
|How to cite this URL:|
Chatterjee P, Mukherjee A, Mitra D, Nautiyal A, Roy A. Superscan on methylene diphosphonate skeletal scintigraphy in prostatic adenocarcinoma: A common finding but rare etiology. Indian J Nucl Med [serial online] 2017 [cited 2022 Aug 12];32:369-71. Available from: https://www.ijnm.in/text.asp?2017/32/4/369/216576
A 57-year-old male patient diagnosed with prostatic adenocarcinoma having Gleason score 5 (2 + 3) and serum prostate-specific antigen (PSA) level 23 ng/ml presented to the Department of nuclear medicine for 99m-techniteum methylene diphosphonate (99m-Tc MDP) skeletal scintigraphy as a part of metastatic workup. 25 mCi of 99m-Tc MDP was injected and skeletal scintigraphy was performed 3 h later which revealed diffusely increased tracer uptake involving both axial and appendicular skeleton with nonvisualization of bilateral kidneys [Figure 1]. In view of history of prostatic adenocarcinoma, a provisional diagnosis of metastatic superscan was made. However, in view of low Gleason score and serum PSA level single emission computed tomography-computed tomography (SPECT-CT) of the pelvic bone was performed for further confirmation. SPECT-CT of the pelvis surprisingly did not reveal any sclerotic lesion [Figure 2]. On further evaluation, it was noted that patient is suffering from chronic renal failure with serum creatinine level was 8 mg/dl. Hence, in the absence of any demonstrable abnormality on SPECT-CT and presence of chronic renal failure differential diagnosis of diffuse marrow metastasis versus metabolic superscan due to chronic renal failure was made. So for further confirmation, bone marrow biopsy and serum parathyroid hormone (PTH) with calcium estimation were advised. Bone marrow biopsy was negative for metastasis. However, blood examination revealed increased serum PTH (972 ng/L) and decreased serum calcium (7.5 mg/dl) confirming diagnosis of metabolic superscan.
|Figure 1: Planar skeletal scintigraphy revealed diffusely increased tracer uptake involving both axial and appendicular skeleton with non-visualization of bilateral kidneys|
Click here to view
|Figure 2: Single emission computed tomography-computed tomography of the pelvis did not reveal any sclerotic lesion|
Click here to view
A superscan is defined as a skeletal scintigraphy which demonstrates markedly increased skeletal uptake relative to soft tissue and is usually with absent or faint genitourinary tract activity., Superscans have been described mostly in metastatic and metabolic bone diseases, and less commonly in myeloproliferative disorders and miscellaneous conditions.,, Among the metastatic causes of superscan prostatic malignancy is the most common cause. However, long-standing prostatic malignancy may resulting in chronic renal failure which is the most common cause of metabolic super scan. Differentiating between metastatic superscan and metabolic superscan is important because treatment modalities are different for two entities. The patterns of uptake between the metastatic and metabolic superscans are different. A metastatic superscan often demonstrates diffuse heterogeneous uptake in the axial skeleton and visualized tracer accumulation in the urinary bladder in spite of absent renal activity, but increased uptake on a metabolic superscan affects both axial and appendicular bones as well as the skull, mandible, and sternum uniformly. However, it is sometimes difficult to differentiate between two entities based on planar scintigraphy. Hence, SPECT-CT should be performed in doubtful cases such as prostatic adenocarcinoma with low Gleason score, low serum PSA level and high serum creatinine level to differentiate between metastatic superscan and metabolic superscan. We, hereby, described a unique case of prostatic adenocarcinoma presented with metabolic superscan and highlighted the importance of SPECT-CT in correctly diagnosing underlying etiology of the superscan.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Osmond JD 3rd
, Pendergrass HP, Potsaid MS. Accuracy of 99mTC-diphosphonate bone scans and roentgenograms in the detection of prostate, breast and lung carcinoma metastases. Am J Roentgenol Radium Ther Nucl Med 1975;125:972-7.
Massie JD, Sebes JI. The headless bone scan: An uncommon manifestation of metastatic superscan in carcinoma of the prostate. Skeletal Radiol 1988;17:111-3.
Buckley O, O'Keeffe S, Geoghegan T, Lyburn ID, Munk PL, Worsley D, et al.
99mTc bone scintigraphy superscans: A review. Nucl Med Commun 2007;28:521-7.
Wilson MA, Calhoun FW, Gaines J, Goldsmith SJ. Patterns of diffusely increased skeletal radiopharmaceutical uptake. Australas Radiol 1981;25:177-80.
Constable AR, Cranage RW. Recognition of the superscan in prostatic bone scintigraphy. Br J Radiol 1981;54:122-5.
Liu Y. Super-superscan on a bone scintigraphy. Clin Nucl Med 2011;36:227-8.
[Figure 1], [Figure 2]