Indian Journal of Nuclear Medicine
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Year : 2018  |  Volume : 33  |  Issue : 4  |  Page : 355-358

Troubleshooting for F-18 fluorocholine synthesis: An institutional experience

1 Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh, Karnataka, India
2 Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuroscience, Bengaluru, Karnataka, India

Correspondence Address:
Rakhee Vatsa
Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.IJNM_85_18

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Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here.

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