Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1657 Print this page  Email this page Small font size Default font size Increase font size
Year : 2020  |  Volume : 35  |  Issue : 1  |  Page : 17-20

Radioiodine therapy of Graves' disease and the uptake paradox

1 Department of Radiotherapy, Nuclear Medicine Division, Kasturba Medical College, Manipal, Karnataka, India
2 Department of Nuclear Medicine, AMRI Hospital, Kolkata, West Bengal, India
3 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Chandrasekar Bal
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.IJNM_158_19

Rights and Permissions

Purpose of the Study: Radioiodine (131I) therapy is approved and well-accepted modality for the treatment of hyperthyroidism. The dosage of131I for successful treatment is based on many factors; however, an objective tool to determine the dose was missing. In a retrospective study, we found that high131I uptake values required more dose to achieve desirable results contrary to the belief. Materials and Methods: Clinically and scintigraphically proven Graves' disease patients with high131I uptake (>50%) were accrued for this study and block randomized into low-dose (Group I) and high-dose (Group II) groups. Low activity (5 mCi) was administered in Group I and higher activity (10 mCi) in Group II. The patients were followed up after 3 months with thyroid function tests to determine the outcome. Results: A total of 344 patients were analyzed at the end of 3 months, with 174 in low-dose group and 170 in high-dose group. Euthyroidism/hypothyroidism was achieved in significantly higher number of patients as compared to the low-dose group. Conclusion: The higher dose of131I is required to achieve euthyroidism/hypothyroidism in patients with high131I uptake.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded241    
    Comments [Add]    

Recommend this journal