Indian Journal of Nuclear Medicine
Home | About IJNM | Search | Current Issue | Past Issues | Instructions | Ahead of Print | Online submissionLogin 
Indian Journal of Nuclear Medicine
  Editorial Board | Subscribe | Advertise | Contact
Users Online: 1902 Print this page  Email this page Small font size Default font size Increase font size

 Table of Contents     
Year : 2020  |  Volume : 35  |  Issue : 2  |  Page : 167-169  

Pulmonary recurrence of lymphomatoid granulomatosis diagnosed on F-18 FDG PET/CT

1 Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Date of Submission22-Sep-2019
Date of Acceptance06-Nov-2019
Date of Web Publication12-Mar-2020

Correspondence Address:
Dr. Apurva Sood
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.IJNM_174_19

Rights and Permissions

Lymphomatoid granulomatosis (LYG) is a rare, extranodal B-cell lymphoproliferative disorder. The disease commonly presents with nonspecific symptoms and imaging features, making the diagnosis and therapeutic response assessment difficult. While histopathology is the mainstay of diagnosis, different imaging modalities such as computed tomography (CT), magnetic resonance imaging, or F18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) can help in identifying the different organs involved. We present a case of LYG, post chemotherapy in remission for the past 5 years, presenting with symptoms of disease recurrence.

Keywords: F-18 FDG PET/CT, lung, lymphomatoid granulomatosis, recurrence

How to cite this article:
Sood A, Parihar AS, Malhotra P, Vaiphei K, Kumar R, Singh H, Mittal BR. Pulmonary recurrence of lymphomatoid granulomatosis diagnosed on F-18 FDG PET/CT. Indian J Nucl Med 2020;35:167-9

How to cite this URL:
Sood A, Parihar AS, Malhotra P, Vaiphei K, Kumar R, Singh H, Mittal BR. Pulmonary recurrence of lymphomatoid granulomatosis diagnosed on F-18 FDG PET/CT. Indian J Nucl Med [serial online] 2020 [cited 2022 Jan 26];35:167-9. Available from:

A 31-year-old-man, diagnosed case of lymphomatoid granulomatosis (LYG) of the lung and soft tissue lesion in the paravertebral location on computed tomography (CT), post six cycles of rituximab-cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (R-CHOP) in remission for the past 5 years, presented with symptoms of fever, malaise, dry cough, and shortness of breath for the past 2 weeks. X-ray of the thorax revealed multiple bilateral lung nodules. The patient underwent F18-fluorodeoxyglucose positron emission tomography/CT (F-18 FDG PET/CT) to look for disease recurrence and site of involvement [Figure 1]. PET/CT showed FDG-avid multiple lung nodules of variable sizes with few non-FDG-avid small thin-walled cysts. Following this, the patient underwent PET/CT guided biopsy of the lung nodule which revealed LYG [Figure 2].
Figure 1: Maximum intensity projection image (a), positron emission tomography only (transaxial b, c and coronal d), computed tomography only (transaxial e, f and coronal g), and positron emission tomography/computed tomography fused (transaxial h, i and coronal j) images showed multiple foci of increased F18-fluorodeoxyglucose uptake in the thorax region (a). Increased uptake localized to multiple lung nodules of variable sizes involving both the lungs (h, dashed arrow; i, white arrow). Few non-F18-fluorodeoxyglucose-avid small thin-walled cysts were also seen (e, arrowhead; g, black arrow)

Click here to view
Figure 2:A patient underwent a biopsy of the lung lesions which showed obliteration of the alveoli cavities by heavy inflammatory cells comprising dominantly of mature lymphocytes intermixed with plasma cells, histiocytes, epithelioid cells, and multinucleated giant cells suggestive of lymphomatoid granulomatosis (H and E, ×250)

Click here to view

LYG is a very rare angiocentric and angiodestructive Epstein–Barr virus-associated B-cell lymphoproliferative disorder.[1] It is more common in men and generally occurs in middle-aged persons. Although lung is the most common organ affected, involvement of other organs such as skin, central nervous system (CNS), kidney, liver, heart, and lymph node has also been documented.[2],[3] The disease commonly presents with nonspecific symptoms such as fever, chest pain, weight loss, and shortness of breath. The rarity of the disease along with nonspecific presentation contributes to the delay in its diagnosis. Recurrence is common and may include refractory disease or progression to high-grade lymphoma seen in ~12% cases. The overall mortality of the disease ranges between 53.0% and 63.5%.[3],[4],[5] While the diagnosis of LYG is done by histopathological examination of the involved sites, imaging features can help in reaching the diagnosis. Pulmonary LYG shares many of the same imaging features with more common condition such as infection, sarcoidosis, pulmonary metastases, Wegener granulomatosis, and pulmonary lymphoma and should always be considered when other more common diagnoses have been excluded. The typical finding of LYG on CT includes multiple irregular, coarse parenchymal nodules largely in the peribronchial distribution or along the interlobular septa. Small thin-walled cystic lesion along with mediastinal lymphadenopathy may also be seen.[6],[7] Magnetic resonance imaging (MRI) is not of much help in the pulmonary LYG as the findings are nonspecific and indistinguishable from lymphoma or inflammatory disorders.[8] However, MRI may prove useful in the diagnosing LYG of the CNS.[9],[10] Lesions of LYG show high metabolic activity on F18-FDG; hence, a whole-body PET/CT scan can assist in accurate mapping of the disease extent in pretherapy scan.[11],[12] Another utility of F18-FDG PET/CT is its potential to be used as an imaging tool to monitor response to therapy and to identify the site of disease in case of suspected recurrence.[13] F18-FDG PET/CT scan done in the present case helped in identifying the site and extent of recurrent disease.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum Pathol 1972;3:457-558.  Back to cited text no. 1
Song JY, Pittaluga S, Dunleavy K, Grant N, White T, Jiang L, et al. Lymphomatoid granulomatosis – A single institute experience: Pathologic findings and clinical correlations. Am J Surg Pathol 2015;39:141-56.  Back to cited text no. 2
Katzenstein AL, Carrington CB, Liebow AA. Lymphomatoid granulomatosis: A clinicopathologic study of 152 cases. Cancer 1979;43:360-73.  Back to cited text no. 3
Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med 1982;306:68-74.  Back to cited text no. 4
Lad D, Malhotra P, Maskey D, Santhosh S, Mittal BR, Das A, et al. Pyrexia, lung nodules, granulomas: Pulmonary lymphomatoid granulomatosis. Indian J Hematol Blood Transfus 2014;30:418-21.  Back to cited text no. 5
Lee JS, Tuder R, Lynch DA. Lymphomatoid granulomatosis: Radiologic features and pathologic correlations. AJR Am J Roentgenol 2000;175:1335-9.  Back to cited text no. 6
Hicken P, Dobie JC, Frew E. The radiology of lymphomatoid granulomatosis in the lung. Clin Radiol 1979;30:661-4.  Back to cited text no. 7
Mendelson DS, Apter S, Kirschner PA, Gendal ES. Magnetic resonance imaging and computed tomography findings in a patient with lymphomatoid granulomatosis. Clin Imaging 1989;13:130-3.  Back to cited text no. 8
Gaha M, Souillard-Scemama R, Miquel C, Godon-Hardy S, Naggara O, Meder JF, et al. MR imaging of the brain and spinal cord in lymphomatoid granulomatosis: A case report and review of the literature. J Neuroradiol 2013;40:364-7.  Back to cited text no. 9
Quinones E, Potes LI, Silva N, Lobato-Polo J. Lymphomatoid granulomatosis of the brain: A case report. Surg Neurol Int 2016;7:S612-6.  Back to cited text no. 10
Rossi G, Marchioni A, Guicciardi N, Bertolini F, Valli R, Cavazza A, et al. Arare cause of fever and PET-positive nodules in the lungs. Clin Respir J 2009;3:118-20.  Back to cited text no. 11
Chung JH, Wu CC, Gilman MD, Palmer EL, Hasserjian RP, Shepard JA, et al. Lymphomatoid granulomatosis: CT and FDG-PET findings. Korean J Radiol 2011;12:671-8.  Back to cited text no. 12
Roarke MC, Nguyen BD. PET/CT characterization and monitoring of disease activity in lymphomatoid granulomatosis. Clin Nucl Med 2007;32:258-9.  Back to cited text no. 13


  [Figure 1], [Figure 2]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Article Figures

 Article Access Statistics
    PDF Downloaded90    
    Comments [Add]    

Recommend this journal