|Year : 2020 | Volume
| Issue : 2 | Page : 170-171
Inflammatory myofibroblastic tumor: Findings on68Ga-DOTA-NOC positron-emission tomography-computed tomography
Sarthak Tripathy1, Mangu Srinivas Bharadwaj1, Sreedharan Thankarajan Arun Raj1, Sameer Rastogi2, Shamim Ahmed Shamim1, Sneha Prakash1
1 Department of Nuclear Medicine and PET-CT, All India Institute of Medical Sciences, New Delhi, India
2 Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
|Date of Submission||09-Nov-2019|
|Date of Acceptance||14-Jan-2020|
|Date of Web Publication||12-Mar-2020|
Dr. Shamim Ahmed Shamim
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi - 110 029
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumors are a rare group of tumors usually affecting children and young adults. They occur in various anatomic locations, with most common being the lung accounting for almost 95% of the cases. We present a case of a 4-year-old girl who presented with fever and dull abdominal pain for 6 months with a clinically palpable left hypochondrium mass. On suspicion of mesenteric/gastric neuroendocrine tumor,68Ga-DOTA-NOC positron-emission tomography-computed tomography was done; however, the biopsy revealed IMT.
Keywords: 68Ga, DOTA-NOC, inflammatory myofibroblastic tumor, positron-emission tomography-computed tomography
|How to cite this article:|
Tripathy S, Bharadwaj MS, Arun Raj ST, Rastogi S, Shamim SA, Prakash S. Inflammatory myofibroblastic tumor: Findings on68Ga-DOTA-NOC positron-emission tomography-computed tomography. Indian J Nucl Med 2020;35:170-1
|How to cite this URL:|
Tripathy S, Bharadwaj MS, Arun Raj ST, Rastogi S, Shamim SA, Prakash S. Inflammatory myofibroblastic tumor: Findings on68Ga-DOTA-NOC positron-emission tomography-computed tomography. Indian J Nucl Med [serial online] 2020 [cited 2022 Jan 26];35:170-1. Available from: https://www.ijnm.in/text.asp?2020/35/2/170/280451
A 4-year-old female presented with dull aching abdominal pain and fever for 6 months to the surgical outpatient department. Per abdominal examination revealed a palpable left hypochondrium mass. Contrast-enhanced computed tomography abdomen was done which revealed lobulated and peripherally enhancing mass measuring approximately 6.6 cm × 6.3 cm × 5 cm in the stomach bed region, likely arising from the greater curvature of the stomach or from the mesentery. On suspicion of neuroendocrine tumor by the concerned clinician, the patient was referred for68 Ga-DOTANOC positron-emission tomography-computed tomography (PET-CT) to look for any additional sites of metastases.68 Ga-DOTA-NOC PET-CT maximum intensity projection image shows increased radiotracer uptake in the abdomen region on the left side [Figure 1]a, solid black arrow] which corresponds to a lobulated mass in the gastric bed region with areas of internal necrosis and calcification on axial and coronal CT images [Figure 1]b and [Figure 1]e, solid white arrows] showing increased DOTA-NOC uptake in the PET only [Figure 1]c and [Figure 1]f and fused PET-CT images [Figure 1]d and [Figure 1]g. Ultrasound-guided biopsy from the left hypochondrium mass showed spindle cell tumor with tumor cells arranged in fascicles, which were infiltrating at places and were embedded in a collagenous background. Immunohistochemistry showed cytoplasmic positivity for smooth muscle actin, desmin, and anaplastic lymphoma kinase-1 and negative for CD117, DOG-1, and myogenin. The overall feature was suggestive of inflammatory myofibroblastic tumor (IMT). The patient underwent surgery after the PET-CT scan as no distant metastasis was present, and the histopathology of the surgical specimen was suggestive of IMT. IMT is an uncommon mesenchymal tumor with an intermediate malignant neoplasm and usually presents in the children and young adults. It can frequently recur and metastasize., Heterogeneity in FDG uptake has been demonstrated in few of the earlier case reports likely due to variability in the population of inflammatory cells in tumor.,,,, Evidence of somatostatin receptor expression has been seldom demonstrated in IMTs and through this the authors want to undermine the fact that IMTs should also be included as a potential differential diagnosis in case of mesenteric mass on68 Ga-DOTA-NOC PET-CT apart from neuroendocrine tumors.
|Figure 1:(a) Maximum intensity projection image of68Ga-DOTA-NOC positron-emission tomography-computed tomography showing increased radiotracer uptake in the left lower abdominal region. (b and e) axial and coronal computed tomography images, respectively, showing a lobulated mass in the left hypochondrium with areas of internal necrosis. (c and f) axial and coronal positron-emission tomography only images, respectively, showing increased radiotracer uptake in the mass lesion. (d and g) axial and coronal fused positron-emission tomography-computed tomography image showing increased radiotracer uptake seen in the left hypochondrium mass lesion|
Click here to view
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Jain A, Kasana S, Ramrakhiani D, Sharma M. Inflammatory myofibroblastic tumor of the stomach in an adult female – Report of a rare case and review of the literature. Turk J Gastroenterol 2012;23:399-405.
Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: Comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol 2007;31:509-20.
Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859-72.
Dua SG, Purandare N, Pramesh CS, Karimundackal G, Menon S, Shah S, et al
. Fluoro-deoxy glucose-avid endobronchial inflammatory myofibroblastic tumor mimicking bronchial malignancy: Report of a case. J Cancer Res Ther 2011;7:340-3.
Kuo PH, Spooner S, Deol P, Monchamp T. Metastatic inflammatory myofibroblastic tumor imaged by PET/CT. Clin Nucl Med 2006;31:106-8.
Athanassiadi K, Laenger F, Dickgreber N, Haverich A. Multiple inflammatory myofibroblastic tumors involving lung and mediastinum: A rare clinical entity. Thorac Cardiovasc Surg 2009;57:343-6.
Dong A, Wang Y, Dong H, Gong J, Cheng C, Zuo C, et al
. Inflammatory myofibroblastic tumor: FDG PET/CT findings with pathologic correlation. Clin Nucl Med 2014;39:113-21.
Ma C, Lu J, Chen G, Wang W, Su F, Su X. Inflammatory myofibroblastic tumor mimicking lymphoma on 18F-FDG PET/CT. Report of a case and review of the literature. Hell J Nucl Med 2018;21:77-80.