Indian Journal of Nuclear Medicine
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Year : 2020  |  Volume : 35  |  Issue : 3  |  Page : 200-202

Compelling case for fostering Titanium-45 for positron emission tomography tracer applications

National Institute of Advanced Studies, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Natesan Ramamoorthy
141 KBL Enclave, Vijayanagara, 4th Stage, 2nd Phase, Mysore - 570 032, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.IJNM_52_20

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The growth of diagnostic nuclear medicine is substantially based on the development, availability, and regular clinical use of cyclotron-based positron emission tomography (PET) tracers. Apart from 18F (110 min) products, the radiometal 68Ga isotope (68 min) has found an increasingly wide clinical acceptance. There is hence much merit in identifying and fostering other radiometal positron emitters, of preferably longer half-life. Titanium-45 (3.08 h) fits the bill well in this context, as it is easy to produce using natural scandium metal target and Ep of 13–14 MeV for 45Sc(p, n) 45Ti reaction. This Commentary cites a compelling case to foster the development of 45Ti products for PET imaging.

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