Indian Journal of Nuclear Medicine
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Year : 2021  |  Volume : 36  |  Issue : 1  |  Page : 90-91

68Ga-prostate-specific membrane antigen uptake as a surrogate biomarker of neovascularity in hepatocellular carcinoma

1 Hull and East Yorkshire Hospitals NHS Trust, Hull, UK
2 Kuwait Cancer Control Centre, Shuwaikh, Kuwait

Correspondence Address:
Dr. Najeeb Ahmed
Jack Brignall PET/CT Centre, Hull and East Yorkshire Hospitals NHS Trust, Hull
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.IJNM_38_20

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68Ga-prostate-specific membrane antigen (68Ga-PSMA) is expressed in the endothelium of tumor-associated neovasculature of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of a 45-year-old man with known colorectal cancer, cirrhosis, and hepatitis C. Contrast-enhanced computed tomography (CT) showed a hypervascular lesion in the liver, and 18F-fluorodeoxyglucose positron emission tomography (PET) did not show any suspicious hepatic uptake. 68Ga-PSMA PET-CT showed predominantly heterogeneous perilesional uptake in a configuration similar to the arterial enhancement pattern on the diagnostic CT. 68Ga-PSMA uptake in hepatocellular carcinoma appears to be primarily neoangiogenesis driven, and its morphological and functional characterization can subsequently influence the selection of anti-neoangiogenic chemotherapy agents as well as guiding radionuclide ligand therapy.

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