Indian Journal of Nuclear Medicine
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Year : 2021  |  Volume : 36  |  Issue : 3  |  Page : 343-346

Fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography in hodgkin's lymphoma: Diagnostic challenge during COVID vaccination

1 Department of Nuclear Medicine, Castle Hill Hospital, Cottingham, UK
2 Kuwait Cancer Control Center (KCCC), Cottingham, UK
3 Jack Brignall PET/CT Centre, Castle Hill Hospital, Cottingham, UK

Correspondence Address:
Dr. Sharjeel Usmani
Department of Nuclear Medicine, Kuwait Cancer Control Center (KCCC), PO Box 1488, 83001 Khaitan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.ijnm_31_21

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Benign metabolic uptake on fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is not uncommonly seen after immunization. We report a case of 30-year-old man with Hodgkin's lymphoma who underwent two cycles of chemotherapy. Interim 18F-FDG PET/computed tomography demonstrated complete metabolic response of prior hypermetabolic bilateral supraclavicular and mediastinal lymph nodes. Although multiple new normal-sized hypermetabolic left axillary and subpectoral lymph nodes are noted, relevant history revealed COVID vaccine 7 days prior scan with mild FDG uptake at the left deltoid muscle. These new findings at the left axilla are likely related to recent vaccination. 18F-FDG PET uptake in the lymph nodes is not so uncommon after immunization; relevant history is very important especially in the phase of massive immunization to avoid false interpretation.

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