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ORIGINAL ARTICLE
Year : 2022  |  Volume : 37  |  Issue : 2  |  Page : 121-125

Comparison of accuracy in calculation of absorbed dose to the kidneys following radioligand therapy with 177Lu-DKFZ-PSMA-617 by two different background correction methods


1 Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Nuclear Medicine, School of Medicine, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Nuclear Medicine, Shohada-e Tajrish Hospital, Tehran, Iran

Correspondence Address:
Dr. Mohammad Reza Deevband
Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.ijnm_134_21

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Background: To improve the accuracy of activity image quality, scatter correction is a critical method. The aim of this study is to compare the accuracy in calculation of absorbed dose to patients following radioligand therapy (RLT) with 177Lu-DKFZ-PSMA-617 by two different methods of background correction in the conjugate view method. Materials and Methods: This study involved 10 patients. The individualized patient dosimetry calculations were based on whole-body planar scintigraphy images acquired in 10 patients with a mean age of 71.4 ± 6.07 years (range 63–85 years) at approximately 0–2 h, 4–6 h, 18–24 h, and 36–48 h after administration of the mean 6253 ± 826.4 MBq (range 5500–7400 MBq) of 177Lu-DKFZ-PSMA-617. Organ activities were calculated using the conjugate view method by Buijs and conventional background correction. Eventually, the absorbed dose of radiation was calculated using Medical Internal Radiation Dose formalism. Results: The dose per unit of injected activity (mGy/MBq) ± standard deviation for kidney using Buijs and conventional methods was 1.05 ± 0.11 and 0.63 ± 0.14, respectively. Conclusion: The Buijs background correction method was more accurate than the conventional method.


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