Indian Journal of Nuclear Medicine
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Year : 2022  |  Volume : 37  |  Issue : 2  |  Page : 126-132

18F-FDG positron emission tomography imaging of cortical reorganization in spinal trauma

Department of Nuclear Medicine and PET-CT Imaging, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India

Correspondence Address:
Dr. Abhinav Jaimini
Department of Nuclear Medicine and PET-CT Imaging, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Timarpur, New Delhi - 110 054, Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnm.ijnm_133_21

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Objective: Spinal cord injury (SCI) extensively impacts the sensorimotor reorganization in the brain. The effects can be both anatomical and functional. To date, not many studies using 18F-Fluoro-2-Deoxyglucose positron emission tomography (18F-FDG PET) to evaluate metabolic changes in the brain are done. Understanding such changes is crucial for developing clinical management and evidence-based rehabilitation strategies for these patients. Subjects and Methods: In this study, we compared 18F-FDG PET imaging of 6 SCI patients with complete paraplegia and 19 controls. Statistical parametric mapping software was utilized to compare the images on a voxel to voxel basis (significance level P < 0.05 and clusters having >50 voxels). Results: The study showed raised metabolism in supplementary motor areas, comprehension centers, some areas in the parietal and temporal lobe, putamen and cerebellum while reduced metabolic uptake in areas like anterior cingulate gyrus, hippocampus and sensory cortical areas when SCI patients were compared against healthy controls. The frontal lobe showed varied results where certain regions showed higher metabolism while the others showed lower in patients compared with controls. Conclusion: Cerebral deafferentation or disuse atrophy can be linked with reduced metabolism while raised uptake can be associated with initiation and planning of movement and cognitive changes in the brain posttrauma.

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