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LETTER TO THE EDITOR
Year : 2022  |  Volume : 37  |  Issue : 2  |  Page : 207  

Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: Correspondence


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, DY Patil University, Pune, Maharashtra, India

Date of Submission25-Nov-2021
Date of Decision28-Nov-2021
Date of Acceptance30-Nov-2021
Date of Web Publication08-Jul-2022

Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, 111 Bangkok, 122 Bangkok 103300
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.ijnm_186_21

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How to cite this article:
Sookaromdee P, Wiwanitkit V. Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: Correspondence. Indian J Nucl Med 2022;37:207

How to cite this URL:
Sookaromdee P, Wiwanitkit V. Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: Correspondence. Indian J Nucl Med [serial online] 2022 [cited 2022 Aug 11];37:207. Available from: https://www.ijnm.in/text.asp?2022/37/2/207/350268



We would like to share ideas on “Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: An In vitro study.[1]” Elessawy et al. concluded that “Our in vitro study practically demonstrated that internal contamination is more hazardous than external exposure.[1]” and “DNA damages are directly associated with increasing irradiation time … contamination and related biological effects.[1]” We agree that internal exposure should be more problematic than external exposure. However, the present model might be difficult to represent an internal exposure due to its nature of in vitro and ex vivo study. All exposures in any group might be considered to get partial or total from external sources. Finally, the analytical technique, comet assay, is recognized as a highly variable investigation with the problem of reproducibility.[2] These factors should be recognized in interpretation of the present in vitro experiment.

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Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Nautiyal A, Mondal T, Goel A, Dey SK, Mitra D. Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: An in vitro study. Indian J Nucl Med 2021;36:288-92.  Back to cited text no. 1
  [Full text]  
2.
Azqueta A, Ladeira C, Giovannelli L, Boutet-Robinet E, Bonassi S, Neri M, et al. Application of the comet assay in human biomonitoring: An hCOMET perspective. Mutat Res Rev Mutat Res 2020;783:108288.  Back to cited text no. 2
    




 

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