|Year : 2022 | Volume
| Issue : 3 | Page : 259-260
A Rare Case of Incidental Finding of Cervical Spinal Cord Hemangioblastoma by 68Ga-DOTATOC Positron Emission Tomography/Computed Tomography Scan
Pietro Bellini, Francesco Dondi, Domenico Albano, Francesco Bertagna
Departement of Nuclear Medicine, Spedali Civili di Brescia and Università degli studi di Brescia, Brescia, Italy
|Date of Submission||10-Dec-2021|
|Date of Acceptance||17-Jan-2022|
|Date of Web Publication||02-Nov-2022|
Dr. Pietro Bellini
Departement of Nuclear Medicine, Spedali Civili di Brescia, P.le Spedali Civili 1, 25123 Brescia
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Hemangioblastomas are rare vascular tumors of the central nervous system usually related to other pathological conditions, such as Von Hippel Lindau Syndrome (VHLS) and polycythemia. We describe a case of a 65-year-old man with a neuroendocrine tumor of the ileum presenting with cervical pain who underwent a 68Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) scan that incidentally underlines the presence of hemangioblastoma of the cervical spinal cord. The patient does not have a family history of VHLS nor does he suffer from polycythemia and he is currently waiting for genetic testing. Despite being rare, hemangioblastomas could be possible findings of central nervous system incidentaloma at 68Ga-DOTATOC PET/CT scan, especially in patients with anamnesis with possible related condition.
Keywords: 68Ga-DOTATOC positron emission tomography/computed tomography, hemangioblastoma, positron emission tomography/computed tomography
|How to cite this article:|
Bellini P, Dondi F, Albano D, Bertagna F. A Rare Case of Incidental Finding of Cervical Spinal Cord Hemangioblastoma by 68Ga-DOTATOC Positron Emission Tomography/Computed Tomography Scan. Indian J Nucl Med 2022;37:259-60
|How to cite this URL:|
Bellini P, Dondi F, Albano D, Bertagna F. A Rare Case of Incidental Finding of Cervical Spinal Cord Hemangioblastoma by 68Ga-DOTATOC Positron Emission Tomography/Computed Tomography Scan. Indian J Nucl Med [serial online] 2022 [cited 2022 Nov 29];37:259-60. Available from: https://www.ijnm.in/text.asp?2022/37/3/259/360269
| Introduction|| |
The 68Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) is an examination usually performed in malignant tumor expressing Type II and V somatostatine receptors, such as low-grade gastroenteropancreatic neuroendocrine tumors (GEP-NET), pheochromocytomas, and paragangliomas. However, also other rarer neoplastic diseases or benign conditions may have increased 68Ga-edotreotide uptake.,
We present a rare case of a patient with a symptomatic hemangioblastoma of the cervical spinal cord incidentally diagnosed in the same PET/CT scan performed for GEP-NET evaluation.
| Case Report|| |
A 65-year-old man with a diagnosis of NET of the ileum (Grading 1, Ki 67 <2%, mitotic index 0–1/10HPF) treated by surgery reported neck and right shoulder pain not responding to therapy with nonsteroidal anti-inflammatory drugs and therefore performed a 68Ga-DOTATOC PET/CT to complete the staging of disease. During imaging evaluation an unexpected uptake of tracer on a 33 mm × 21 mm mass inside the spinal canal near C1–C2, explaining the cervical pain, was found [Figure 1]. No other uptakes suspicious for NET localization were present. Considering the grading of the tumor, the site of the uptake, and disease status in 68Ga-DOTATOC PET/CT, the incidental findings appeared unrelated to the primary NET and the lesion did not present characteristics of meningioma.
|Figure 1: 68Ga-DOTATOC positron emission tomography/computed tomography coronal (a), sagittal (b) and transaxial (c) fused images show an intense uptake corresponding to a mass inside the cervical spinal canal. After surgical excision and histological examination the diagnosis of hemangioblastoma was formulated|
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A subsequent magnetic resonance imaging (MRI) scan excluded the diagnosis of meningioma, but it did not resolve the diagnostic doubt about the spinal mass nature [Figure 2]. Finally, the patient underwent neuro-surgical excision of the lesion and after histological examination, a final diagnosis of hemangioblastoma was formulated. No pancreatic cysts or blood count alterations were found during diagnostic iter and anamnesis did not show the familiar history of hemangioblastoma or Von Hippel Lindau Syndrome (VHLS). The patient is actually in follow-up and waiting for genetic test for the research of 3p25.3 mutation.
|Figure 2: Magnetic resonance imaging coronal (a) and sagittal (b) T1 FSE with contrast agent images of the cervical spinal cord mass show an intense uptake of contrast agent|
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| Discussion|| |
Hemangioblastoma is a tumors of the central nervous system (CNS) originating from vascular cells, usually associated with VHLS or other pathological conditions like polycythemia and pancreatic cysts. The most common sites of disease localization are the cerebellum and brain stem, but the spinal cord could be involved too.
Diagnosis of hemangioblastoma is usually performed by imaging examinations, such as CT or MRI, but the histological characterization is mandatory. The treatment is based on surgical excision or radiosurgery.
When quite frequent pathological conditions such as meningioma were excluded, despite the very low incidence, it is important to consider hemangioblastoma as a possible alternative diagnosis of incidental uptake involving the CNS in 68Ga-DOTATOC PET/CT, especially in patients with anamnesis of VHLS, renal cysts or polycythemia.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that his name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Bashir A, Broholm H, Clasen-Linde E, Vestergaard MB, Law I. Pearls and pitfalls in interpretation of 68Ga-DOTATOC PET imaging. Clin Nucl Med 2020;45:e279-80.
Dondi F, Albano D, Bertagna F, Giubbini R. Incidental uterine fibroid detected by 68Ga-DOTATOC PET/CT scan in patient with ileal neuroendocrine tumor. Rev Esp Med Nucl Imagen Mol (Engl Ed) 2021;40:334-6.
Chittiboina P, Lonser RR. Von Hippel-Lindau disease. Handb Clin Neurol 2015;132:139-56.
Lasocki A, Akhurst T, Drummond K, Gaillard F. Cerebellar haemangioblastoma discovered incidentally on (68) Ga-DOTA-octreotate examination. Clin Neurol Neurosurg 2016;144:20-2.
Sharma P, Dhull VS, Bal C, Malhotra A, Kumar R. Von Hippel-Lindau syndrome: Demonstration of entire disease spectrum with (68) Ga-DOTANOC PET-CT. Korean J Radiol 2014;15:169-72.
[Figure 1], [Figure 2]