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Year : 2022  |  Volume : 37  |  Issue : 3  |  Page : 279-280

Incidental findings of acute myeloid leukemia in Sjögren's syndrome detected by nuclear medicine techniques


Department of Oncological Medical and Specialists, Nuclear Medicine Unit, University Hospital of Ferrara, Ferrara, Italy

Correspondence Address:
Dr. Luca Urso
Department of Oncological Medical and Specialists, Nuclear Medicine Unit, University Hospital of Ferrara, Via Aldo Moro 8, CAP 44124, Ferrara
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnm.ijnm_126_21

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A 46-year-old female with Sjögren's syndrome previously treated with corticosteroids was referred to our department for suspicious humeral head osteonecrosis. Dual-phase bone scan showed an increased radiotracer distribution in the head of the left humerus. Nevertheless, whole-body scan revealed multiple sites of heterogeneous skeletal uptake. As lymphoproliferative disorder was hypothesized, also based on laboratory examination, F-18 fluorodeoxyglucose positron-emission tomography/computed tomography was performed and showed increased uptake in several osseous structures and in the subcutaneous nodules. Finally, bone marrow biopsy confirmed the diagnosis of acute myeloid leukemia as well as skin nodule biopsy revealed infiltration by malignant cells.


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