Indian Journal of Nuclear Medicine

: 2017  |  Volume : 32  |  Issue : 2  |  Page : 159--161

PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET/MRI

Amarnath Jena1, Shuaib Zaidi2, Vikas Kashyap3, Abhishek Jha1, Sangeeta Taneja1,  
1 Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India
2 Department of Surgical Oncology, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India
3 Department of Pathology, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India

Correspondence Address:
Dr Amarnath Jena
Senior Consultant, Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi


PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Abnormal PSMA uptake in the thyroid gland prompted USG-guided FNAC which revealed Hurthle cell neoplasm. Histopathological examination (HPE) of excised gland showed multiple Hurthle cell adenomas in both lobes of thyroid along with foci of papillary thyroid carcinoma which on immunohistochemistry were thyroglobulin positive and PSA negative.

How to cite this article:
Jena A, Zaidi S, Kashyap V, Jha A, Taneja S. PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET/MRI.Indian J Nucl Med 2017;32:159-161

How to cite this URL:
Jena A, Zaidi S, Kashyap V, Jha A, Taneja S. PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET/MRI. Indian J Nucl Med [serial online] 2017 [cited 2022 Oct 7 ];32:159-161
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 Case report

A 66-year-old male with the history of prostate carcinoma, who underwent transurethral resection of the prostate 2 years back with raised PSA level and suspected spinal metastases, was referred for Ga-68-PSMA whole-body simultaneous PET/MRI scan for restaging. A bulky T2W hypointense mass was noted in residual prostate involving right seminal vesicle [Figure 1]a with the base of the bladder and mesorectal fascia, showing diffusion restriction [Figure 1]b and [Figure 1]c, increased Ktrans [Figure 1]d and increased PSMA uptake SUV max = 12.1 to 21.1 [Figure 1]e and [Figure 1]f. No enlarged/PSMA avid nodes were seen. Widespread PSMA avid marrow lesions were seen extensively involving the spine [Figure 1]g and [Figure 1]h and the remaining skeleton with SUV max = 8.5 to 27.5 [Figure 1]i.{Figure 1}

Further, an enlarged thyroid gland showing multiple nodules of varying intensity and sizes involving both lobes [Figure 2]a-[Figure 2]c was observed with focal increased PSMA uptake [Figure 2]d-[Figure 2]f on the left side with SUV max = 5.9. No enlarged/ PSMA avid nodes were seen in bilateral neck.{Figure 2}

USG-guided FNAC of thyroid was done which was reported as Hurthle cell neoplasm. Subsequently, total thyroidectomy was performed and the excised gland was sent for HPE which revealed multiple large nodules in both lobes consistent with Hurthle cell adenoma [Figure 3]a. In addition, small sub centimeter foci showing tubule-papillary architecture of papillary carcinoma [Figure 3]b were also noted in both lobes of thyroid. Subsequently, immunohistochemistry analysis was carried out and the thyroid lesions were found to show intense expression for thyroglobulin [Figure 3]c and no expression for PSA [Figure 3]d thereby ruling out metastases from PCa and proving that it is a primary thyroid neoplasm. A small pretracheal node sampled during surgery was reported to have metastases from papillary thyroid carcinoma based on its follicular architecture [Figure 3]e and [Figure 3]f. The pretracheal node was positive for thyroglobulin and negative for PSA [Figure 3]g and [Figure 3]h. Central compartment neck lymph nodes showed no evidence of metastases. There was no lymphovascular, perineural, capsular invasion and extension into the perithyroidal soft tissue associated with any of the tumors.{Figure 3}


PSMA based simultaneous PET/MRI is a novel imaging technique which has been used in diagnosis of recurrent prostate carcinoma.[1] PSMA uptake has been demonstrated in both non-prostatic neoplastic[2],[3],[4],[5],[6] and non-neoplastic lesions.[7],[8] PSMA uptake is also seen in both benign[9] and malignant neoplasms of thyroid.[10],[11],[12] Although rare, metastatic spread to the thyroid gland from primary PCa has been reported in the past.[13],[14] In this patient, metastases to the thyroid was a distinct possibility in view of widespread metastatic disease not observed in this case. So, in a case of PSMA avid thyroid lesion, it is important to differentiate metastases with primary thyroid neoplasm with biopsy before initiating further treatment.


Pradeep Negi for technical help in study acquisition and preparation of manuscript

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest


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