ORIGINAL ARTICLE
Year : 2018 | Volume
: 33 | Issue : 1 | Page : 20--24
Vitamins E and C prevent DNA double-strand breaks in peripheral lymphocytes exposed to radiations from iodine-131
Mehdi Safaei1, Seyed Masoud Jafarpour1, Mehran Mohseni1, Morteza Salimian2, Hossein Akbari3, Fateme Karami4, Akbar Aliasgharzadeh1, Bagher Farhood1
1 Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
2 Department of Medical Laboratory, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
3 Department of Biostatistics, Faculty of Health Sciences, Kashan University of Medical Sciences, Kashan, Iran
4 Department of Nuclear Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
Correspondence Address:
Dr. Mehran Mohseni
Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan
Iran
Purpose: Iodine-131 is used as a radiopharmaceutical to treat thyroid cancer. The current study aimed to evaluate the effects of vitamins E and C on the level of DNA double-strand breaks (DSBs) caused by Radioiodine-131 (I-131) in human lymphocytes. Materials and Methods: Whole blood samples from human volunteers were incubated with a certain concentration of vitamins. After 1-h incubation, the samples were incubated with 20 μCi I-131/2 mL (blood + NaCl) for 1 h. To evaluate the effects of antioxidants, lymphocytes were separated, and the mean DSBs/cell was measured for each sample through γ-H2AX assay. Results: After 1-h incubation with 20 μCi I-131/2 mL (blood + NaCl), iodine-131 increased the level of DSBs by 102.9%, compared with the background group. Vitamins E and C reduced the level of DSBs by 21.5% and 36.4%, respectively. Conclusion: Using vitamins E and C as antioxidants can reduce the toxicity of I-131. Furthermore, vitamin C provided the more protection for DNA, compared with vitamin E.
How to cite this article:
Safaei M, Jafarpour SM, Mohseni M, Salimian M, Akbari H, Karami F, Aliasgharzadeh A, Farhood B. Vitamins E and C prevent DNA double-strand breaks in peripheral lymphocytes exposed to radiations from iodine-131.Indian J Nucl Med 2018;33:20-24
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How to cite this URL:
Safaei M, Jafarpour SM, Mohseni M, Salimian M, Akbari H, Karami F, Aliasgharzadeh A, Farhood B. Vitamins E and C prevent DNA double-strand breaks in peripheral lymphocytes exposed to radiations from iodine-131. Indian J Nucl Med [serial online] 2018 [cited 2023 Jan 27 ];33:20-24
Available from: https://www.ijnm.in/article.asp?issn=0972-3919;year=2018;volume=33;issue=1;spage=20;epage=24;aulast=Safaei;type=0 |
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