Mismatch in Brain Perfusion and Metabolism Detected with <sup>99m</sup>Tc-Hexamethyl Propylene Amine Oxime Single Photon Emission Computed Tomography and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in Moyamoya Disease :Justo Serrano Vicente, Luis Fernández Prudencio, José Rafael Infante Torre, Juan Ignacio Rayo Madrid, Indian Journal of Nuclear Medicine

CASE REPORT
Year : 2018 | Volume : 33 | Issue : 2 | Page : 154--157

Mismatch in Brain Perfusion and Metabolism Detected with ^99mTc-Hexamethyl Propylene Amine Oxime Single Photon Emission Computed Tomography and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in Moyamoya Disease

Justo Serrano Vicente, Luis Fernández Prudencio, José Rafael Infante Torre, Juan Ignacio Rayo Madrid
Department of Nuclear Medicine, Infanta Cristina Hospital, Badajoz, Spain

Correspondence Address:
Dr. Justo Serrano Vicente
Hospital Infanta Cristina de Badajoz, Avda. Elvas SN. 06010, Badajoz
Spain

Abstract

We report a 47-year-old woman who developed an ischemic stroke with diplopia and dysarthria. Emergency computed tomography (CT) showed no pathological findings, and magnetic resonance (MR) showed mild ischemic-degenerative lesions. MR angiography and angiogram showed severe stenosis of both internal carotid and main intracranial arteries with plenty collateral vessels with “puff of smoke” suggesting a moyamoya disease (MMD). Brain perfusion single-photon emission CT showed global diminished perfusion in the brain lobes and a marked relative hyperperfusion in the cerebellum. However, brain ¹⁸F-fluorodeoxyglucose-positron emission tomography showed physiological metabolism in the brain cortex with only slightly relative cerebellar hypermetabolism. MMD is a well-known arterial pathology that frequently develops with only mild symptoms until the middle age. Functional neuroimaging findings indicate a mismatch between brain glucose metabolism and brain perfusion, probably due to neuronal subclinical chronic ischemia in the brain cortex with preserved viability of neurons.

How to cite this article:
Vicente JS, Prudencio LF, Infante Torre JR, Rayo Madrid JI. Mismatch in Brain Perfusion and Metabolism Detected with ^99mTc-Hexamethyl Propylene Amine Oxime Single Photon Emission Computed Tomography and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in Moyamoya Disease.Indian J Nucl Med 2018;33:154-157

How to cite this URL:
Vicente JS, Prudencio LF, Infante Torre JR, Rayo Madrid JI. Mismatch in Brain Perfusion and Metabolism Detected with ^99mTc-Hexamethyl Propylene Amine Oxime Single Photon Emission Computed Tomography and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in Moyamoya Disease. Indian J Nucl Med [serial online] 2018 [cited 2023 Mar 24 ];33:154-157
Available from: https://www.ijnm.in/text.asp?2018/33/2/154/227512

Full Text

Introduction

Moyamoya disease (MMD) was first described in 1957 as a “bilateral hypoplasia of internal carotid arteries.”[1] The name of the disease comes from Japanese and means “puff of smoke.” Modern methods of brain vessel imaging, such as computed tomography (CT) angiography, magnetic resonance imaging (MRI) angiography, or rotational digital subtraction angiography, lead to a more frequent diagnosis of asymptomatic cases of this disease.[2] Functional neuroimaging such as positron emission tomography (PET) and single-photon emission CT (SPECT) can provide additional information that may be helpful in the management of this disease.[3]

Case Report

We present a 47-year-old female who was requested to the hospital due to decreased visual acuity and diplopia. After reading for a short time, she developed a headache, more acute on the left side. In the emergency room, the patient developed difficulty in speaking, a hypertensive crisis, and anxiety. Biochemical analysis showed no pathologic findings. A brain CT was performed and reported as normal.

One day later, a brain magnetic resonance (MR) was carried out showing a focal acute stroke located in the midbrain noted on diffusion-weighted imaging and in T2-fluid attenuated inversion recovery sequence [Figure 1].{Figure 1}

Two months after hospitalization, a brain and aortic MR angiography was carried out showing bilateral occlusion of cervical segment internal carotid arteries. Based on these findings, MMD was suspected. Then, angiogram confirmed the extensive perforator collaterals from external carotid arteries giving the “puff of smoke” characteristic of this disease, involving both anterior and posterior circulation [Figure 2].{Figure 2}

Four months later, a brain perfusion SPECT with 99m Tc-hexamethyl propylene amine oxime was requested, showing a relative diminished perfusion of all brain lobes, more pronounced in occipital, posterior temporal, and adjacent parietal cortex. The most relevant finding was a marked increase in perfusion in the cerebellum compared to the rest of the brain structures. Basal ganglia also showed preserved perfusion [Figure 3]a and [Figure 4]a.{Figure 3}{Figure 4}

Two weeks later, a revascularization was planned and the patient was referred to our department to perform a brain 18 F-fluorodeoxyglucose-PET (FDG-PET) to assess the viability of encephalic territories. Unexpectedly, despite the SPECT findings, the images showed a preserved metabolism of glucose in the brain lobes. The only finding was a slightly relative elevated metabolism in the cerebellum. Unfortunately, the revascularization procedure was ruled out due to technical impediments [Figure 3]b and [Figure 4]b.

Currently, the patient remains asymptomatic, with only mild dysarthria, attending periodic follow-up with the neurologist.

Discussion

Moyamoya is a well-known rare occlusive disorder of cerebral vasculature with poorly understood etiology. Genetic background is frequently mentioned because, in 15% of cases, the disease is found in other family members. These are most probably the cases of multifactorial autosomal inheritance.[1] The disease is characterized by progressive intracranial vascular stenosis of the circle of Willis, resulting in successive ischemic events. Hemorrhagic events can also occur. Diagnosis is established by the typical appearance on cerebral angiography, i.e., “puff of smoke” and refers to the appearance of multiple compensatory dilated striate vessels seen on angiography. CT and MRI play a major role in documenting the regions of infarction/hemorrhage. In these patients, chronic stenosis of the brain vessels causes a chronic hemodynamic stress and induces formation if new collateral vessels.[2] Functional neuroimaging studies with PET are used in MMD to evaluate the cerebral perfusion employing radiotracers like H2(15 O) and the viability of the cerebral territories using FDG. Brain perfusion SPECT is also employed for the assessment of blood flow reserve of the brain (using acetazolamide challenge),[3] prediction of MMD progression,[4] patient follow-up,[5] prognostic before and after revascularization interventions, and detection of regional perfusion impairment of family members in familial cases.[6]

In this case, the unusual finding is the mismatch between perfusion and metabolism of the brain. Brain perfusion SPECT showed marked alterations in the brain cortical perfusion with relative elevated perfusion in the cerebellum while brain FDG-PET showed near normal distribution in cortical glucose metabolism and slightly relative elevated cerebellum metabolism [Figure 3] and [Figure 4]. Certain mismatch phenomena such as the “luxury perfusion” have been described in cerebrovascular diseases such as acute stroke,[7] but we have not found any similar case in literature. We can only describe relative decreases in perfusion since we do not have specific quantification software such as SPM. Our descriptions are qualitative compared to the normal distribution pattern of both tracers in the brain, but the SPECT findings suggested that the cerebellum showed a relative increased perfusion compared to the rest of the structures, whereas PET showed almost a normal distribution. Regarding the relative augmented perfusion in the cerebellum, it has been described that in advanced dementias, the cerebellar metabolism tends to increase progressively, likely as part of a compensatory mechanism that involves recruitment of alternate neuronal pathways.[8] In other neurodegenerative diseases such as Parkinson's disease, a progressive increase in cerebellar perfusion has been depicted, as a compensatory change that occurs as a consequence dysfunction in other neural structures.[9] This neural plasticity, developing and preserving some structures and circuits in a trend to compensate the dysfunction of other neural regions, has been described in the physiopathology of dementias.[10] MMD is a rare disease in which functional neuroimaging plays a minor role in its management, but in the case reported, SPECT and PET showed additional information that might help us understand the physiopathology of this disorder.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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