Indian Journal of Nuclear Medicine
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   2010| January-March  | Volume 25 | Issue 1  
    Online since May 22, 2010

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Scintigraphic and radiological correlative and confirmative features obviating invasive biopsy in caffey's disease
M Ranadheer, Santhi Bhushan Murari, N Sujith, Jayanthi , Pushpalatha Sudhakar, VVS Prabhakar Rao
January-March 2010, 25(1):20-22
DOI:10.4103/0972-3919.63595  PMID:20844665
Caffey's disease is not a common clinical occurrence; it often poses problems in diagnosis due to its close resemblance to osteomyelitis. Initial plain radiographic diagnosis is sometimes fraught with the limitation of not being able to differentiate it from chronic osteomyelitis. Skeletal scintigraphy is sensitive in localizing the disease activity to the radiological features of the affected regions and the characteristic location of the lesions helps make the diagnosis without resorting to biopsy and further workup.
  5,901 174 1
PET-MRI: Challenges and new directions
Aditya Daftary
January-March 2010, 25(1):3-5
DOI:10.4103/0972-3919.63590  PMID:20844660
  4,980 548 5
Sestamibi (99mTc) scan as a single localization modality in primary hyperparathyroidism and factors impacting its accuracy
Yousof Alabdulkarim, Edgard Nassif
January-March 2010, 25(1):6-9
DOI:10.4103/0972-3919.63591  PMID:20844661
Background The proper localization of a hypersecreting parathyroid gland is of vital importance for successful unilateral neck exploration (UNE) and parathyroidectomy. Aim: In this study we aim to evaluate the (99mTc) sestamibi parathyroid scan as a single localizing modality, and we also assess its relation to the weight of the gland and to the preoperative parathyroid hormone (PTH) levels. Patients and Methods: We reviewed 170 patients from our hospital (Notre-Dame hospital) from 2005 to 2008, with a mean age of 56.6 years and a female to male ratio of 3.3:1. With primary hyperparathyroidism, all of them had (99mTc) sestamibi parathyroid scan for the localization of the parathyroid adenoma. Preoperative and postoperative PTH levels were recorded. The histopathology reports confirmed the diagnosis and weight of the diseased gland, which were recorded every time. The results were analyzed and correlated with the sestamibi results, to evaluate its accuracy. Results: Seventy-eight patients (41%) of the 170 had an exact match (EM) sestamibi results,81 (51.6%) had a partial match, and only 11 patients were reported as mismatch. Analyzing the mean weight of the gland in each group between matching (EM, PM) versus mismatch resulted in a mean difference of 0.823 g (1.05 and 0.247 g, respectively) P = 0.045. Hyperplasia to adenoma ratio was more in the partial matching group (18.5%) versus the exact matching group (7.6%). Finally the mean PTH level was higher in the EM group (28.8 pmol/L) compared to the mismatch group (10.1 pmol/L) P = 0.02. Overall sensitivity and specificity for the (99 mTc) sestamibi in our data was 98.1 and 97%, respectively. Conclusion: (99mTc) sestamibi is a highly accurate test that can be employed as a single localizing modality for identifying a hypersecreting parathyroid, a UNE, or a parathyroidectomy.The weight of the gland plays an important role in the accuracy of the test, as also the preoperative PTH levels.
  3,877 281 5
Tc-MDP bone scintigraphy in a case with sporodical tumoral calcinosis
Tulay Kacar Guveli, Mehmet Mulazimoglu, Muge Oner Tamam, Cuneyt Tamam, Tarik Tatoglu, Tevfik Ozpacaci
January-March 2010, 25(1):27-28
DOI:10.4103/0972-3919.63598  PMID:20844668
Tumoral calcinosis is an uncommon and benign condition characterized by the presence of large calcific soft tissue deposits occurring predominantly in a periarticular location. It generally occurs as a complication of renal dialysis or trauma, and is rarely seen in familial and sporadic cases. Bone scintigraphy is a sensitive method for diagnosing tumoral calcinosis. A 28-year-old female patient with a history of operation due to tumoral calcinosis located bilateral hips, referred to our department. She had a tender palpable mass in the right knee and a fistulized incisional scar overlying the bilateral hip joints. A sporadic case of tumoral calcinosis with relapses was presented.
  3,861 128 -
Physical dosimetry and mathematical dose calculation in nuclear medicine: A comparative study
Ali Shabestani Monfared, Mehrangiz Amiri
January-March 2010, 25(1):10-11
DOI:10.4103/0972-3919.63592  PMID:20844662
Objectives : This paper addresses a comparison between physical dosimetry and mathematical dose calculation in nuclear medicine. Materials and Methods: Dose rate was calculated by mathematical external dose calculation formula and by physical dosimetry from the surface of 38 adult patients' body referred to nuclear medicine department. Results of the methods were compared and correlation and regression tests were also performed. Results: Although the physical dosimetry data in this study are in good consistency with other researches, they are much lower than the results of mathematical dose calculation formula. The correlation coefficient between measured dose rate with calculated values derived by mathematical formula was found to be 0.852 (P value=0.148). Conclusion: It seems that physical dosimetry data are more accurate than the results of mathematical dose calculation. In case of using mathematical dose calculation formula, other correction factors should be considered and applied for getting reliable data.
  3,660 286 2
Message from SNM President
BR Mittal
January-March 2010, 25(1):2-2
DOI:10.4103/0972-3919.63589  PMID:20844659
  3,252 181 -
Utility of Iodine-131 hybrid SPECT-CT fusion imaging before high-dose radioiodine therapy in papillary thyroid carcinoma
Anish Bhattacharya, Sunil Hejjaji Venkataramarao, Chandra Sekhar Bal, Bhagwant Rai Mittal
January-March 2010, 25(1):29-31
DOI:10.4103/0972-3919.63599  PMID:20844669
The management protocol for differentiated thyroid cancer includes whole body iodine-131 imaging, to detect residual thyroid tissue and distant metastasis, after thyroidectomy. However, the diagnostic dose of radioiodine may fail to detect the non-functioning or poorly functioning metastasis. We present a case where hybrid single photon-emission computed tomographic and computed tomographic (SPECT-CT) fusion imaging, using a diagnostic dose of iodine-131, was able to detect both functioning as well as non-functioning pulmonary metastases, prior to high-dose radioiodine therapy.
  3,079 244 5
Tc99m MDP bone SPECT in a case of osteomyelitis of the skull
Ravinder Singh Sethi, BR Mittal, Anish Bhattacharya, Baljinder Singh
January-March 2010, 25(1):25-26
DOI:10.4103/0972-3919.63597  PMID:20844667
A seven-year-old male child presented with swelling at the left temporal region. His skull X-ray was normal. A three-phase bone scan showed increased blood flow, soft tissue activity, and increased tracer concentration in the left temporal region. Single photon emission computed tomography (SPECT) imaging of the skull revealed full thickness involvement of the left temporal bone. Our case report shows that, in osteomyelitis of the skull, SPECT imaging provides significantly more information for identifying the extent and thickness of bone involvement.
  2,710 149 3
Absent right iliac bone on Tc99m MDP bone scan in a patient with Gorham's vanishing bone disease
Saleh Othman
January-March 2010, 25(1):23-24
DOI:10.4103/0972-3919.63596  PMID:20844666
Gorham's (vanishing bone) disease is an extremely rare condition of the bone. The diagnosis is usually made on the basis of the characteristic history of osteolysis and failure of bone healing in conjunction with the histological findings of marrow fibrosis and increased vascularity. When the disease is established, an X-ray and magnetic resonance imaging show complete loss of affected bone. There are very few reports found in literature on bone scan appearance of the disease. A bone scan of a 24-year-old female patient with known Gorham's disease revealed absence of tracer uptake in the right iliac bone, right sacroiliac joint, and part of the right ischial pubic rami, which matched the radiographic abnormalities. Consequently this disease should be added to the gamut of cold defects seen on bone scan.
  2,637 144 3
Tc-99m radio-guided completion thyroidectomy for differentiated thyroid carcinoma
Savas Karyagar, Oguzhan Karatepe, Omer Bender, Mehmet Mulazimoglu, Tevfik Ozpacaci, Ercan Uyanik, Sevda S Karyagar, Orhan Yalcin, Yasar Ozdenkaya
January-March 2010, 25(1):12-15
DOI:10.4103/0972-3919.63593  PMID:20844663
Background : The purpose of this study is to investigate whether or not radio-guided surgery has any beneficial effects on completion thyroidectomy (CT) and the associated complication rates. Patients and Methods: Twenty-seven patients were scheduled for CT, for thyroid carcinoma, from December 2004 to June 2005, and were included in the study. All the patients had had initial thyroid surgery in other centers and been referred to our clinic for CT. Operation findings and the effectiveness of Tc-99m radio-guided CT were analyzed. Results: The intraoperative mean ratio of thyroid activity to background activity counted with a gamma probe was 1.3 0.3. Average operation timing was 74 9 minutes. Postoperatively, no residual tissue was detected in any of the patients with ultrasonography and thyroid scintigraphy. In the first postoperative month, serum TSH level was 61 16.4 mIU / L, when preoperatively it was 7.3 3.1 mIU / L (P < 0.001). In the postoperative period, one patient experienced temporary hypoparathyroidism (3.9%). Permanent hypoparathyroidism or recurrent laryngeal nerve damage was not detected in any patient. Conclusion: Tc-99 radio-guided CT is a reliable surgical method, which provides the detection and removal of residual thyroid tissues with minimal complications.
  2,436 175 -
Nidus localization in osteod osteoma by SPECT skeletal scintigraphy: Aid to diagnosis and surgical approach
Santhi Bhushan Murari, N Sujith, M Ranadheer, P Chandra Sekhar, P Aruna Kumari, VVS Prabhakar Rao
January-March 2010, 25(1):16-19
DOI:10.4103/0972-3919.63594  PMID:20844664
Osteod osteoma, although not a common clinical occurrence, does pose problems both in diagnosis and surgical management. Initial plain radiographic diagnosis is sometimes fraught with the limitation of not being able to differentiate from chronic osteomyelitis and stress fracture. CT-aided localization of the nidus is also often inconclusive. Radionuclide single photon emission computed tomography (SPECT) scintigraphy is highly sensitive in localizing the active nidus and also orients the lesion in a three-dimensional plane well, for effective surgical removal
  2,186 151 -
A new beginning...
Anshu Rajnish Sharma
January-March 2010, 25(1):1-1
DOI:10.4103/0972-3919.63588  PMID:20844658
  1,994 246 -
Closed system vacuum assisted administration of high dose radio iodine to cancer thyroid patients: NIMS techniqe
VVS Prabhakar Rao, Pushpalatha Sudhakar, V Kumara Swamy, G Pradeep, N Venugopal
January-March 2010, 25(1):34-35
DOI:10.4103/0972-3919.63601  PMID:20844671
  2,049 169 -
Utility of hybrid SPECT-CT in the detection of unsuspected single lytic vertebral metastases in renal cell carcinoma
CNB Harisankar, Bhagwant Rai Mittal, Anish Bhattacharya, Baljinder Singh
January-March 2010, 25(1):32-33
DOI:10.4103/0972-3919.63600  PMID:20844670
Authors describe the incremental value of hybrid SPECT-CT in upstaging disease and changing the management strategy of a case of renal cell carcinoma
  1,701 136 -