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  Indian J Med Microbiol
 

Figure 3: Histopathology revealing a diffuse astrocytoma (WHO grade II) characterized by moderately pleomorphic cells set against a pale fibrillary background. No mitoses, endovascular proliferation, or necrosis is identified (a, H&E x200; b, H&E x400). c: Neoplastic cells revealed immunoreactivity for IDH1 R132H mutant protein; d: Loss of expression for ATRX protein (mutant phenotype). (c,d: immunoperoxidase x400)

Figure 3: Histopathology revealing a diffuse astrocytoma (WHO grade II) characterized by moderately pleomorphic cells set against a pale fibrillary background. No mitoses, endovascular proliferation, or necrosis is identified (a, H&E x200; b, H&E x400). c: Neoplastic cells revealed immunoreactivity for IDH1 R132H mutant protein; d: Loss of expression for ATRX protein (mutant phenotype). (c,d: immunoperoxidase x400)